Table 5.
Risk of SCC, adenocarcinoma of the cervix, and squamous cell vulvar cancer associated with selected class I and II multilocus genotypes
| Controls (N=502) |
SCC Cervix (n=490) |
Adenocarcinoma (n=537) |
Controls2 N=637) |
SCC Vulvar (n=424) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | OR1 | (95% CI) | n | (%) | OR1 | (95% CI) | n | (%) | n | (%) | OR1 | (95% CI) | |
| B*4402-DRB1*1101-DQB1*0301 | ||||||||||||||||
| X-X-X | 312 | (62.0) | 253 | (52.0) | ref | 309 | (57.5) | ref | 380 | (59.7) | 224 | (52.8) | ref | |||
| 4402-X-X | 35 | (7.0) | 38 | (7.8) | 1.4 | (0.9-2.3) | 43 | (8.0) | 1.3 | (0.8-2.0) | 46 | (7.2) | 23 | (5.4) | 0.8 | (0.5-1.4) |
| X-1101-X | 3 | (0.6) | 0 | (0.0) | -- | 1 | (0.2) | 0.3 | (0.0-2.7) | 5 | (0.8) | 1 | (0.2) | 0.4 | (0.0-3.1) | |
| X-X-0301 | 92 | (18.3) | 91 | (18.7) | 1.2 | (0.9-1.7) | 100 | (18.6) | 1.1 | (0.8-1.5) | 112 | (17.6) | 56 | (13.2) | 0.8 | (0.6-1.2) |
| 4402-1101-X | 0 | (0.0) | 1 | (0.2) | -- | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |||||
| 4402-X-0301 | 32 | (6.4) | 45 | (9.2) | 1.8 | (1.1-3.0)* | 37 | (6.9) | 1.2 | (0.7-2.0) | 47 | (7.4) | 40 | (9.4) | 1.4 | (0.9-2.3) |
| X-1101-0301 | 26 | (5.2) | 31 | (6.4) | 1.5 | (0.8-2.5) | 33 | (6.1) | 1.3 | (0.8-2.2) | 39 | (6.1) | 58 | (13.7) | 2.5 | (1.6-3.9)* |
| 4402-1101-0301 | 3 | (0.6) | 28 | (5.7) | 11.5 | (3.5-38.5)* | 14 | (2.6) | 4.9 | (1.4-17.2)* | 8 | (1.3) | 22 | (5.2) | 4.7 | (2.0-10.7)* |
| B*0702-Cw*0702-DQB1*0301 | ||||||||||||||||
| X-X-X | 237 | (47.1) | 201 | (41.0) | ref | 225 | (41.9) | ref | 296 | (46.5) | 161 | (38.0) | ref | |||
| 0702-X-X | 2 | (0.4) | 0 | (0.0) | -- | 2 | (0.4) | 1.1 | (0.2-7.9) | 3 | (0.5) | 3 | (0.7) | 1.8 | (0.4-9.2) | |
| X-0702-X | 10 | (2.0) | 11 | (2.2) | 0.9 | (0.4-2.3) | 11 | (2.0) | 1.1 | (0.4-2.6) | 15 | (2.4) | 4 | (0.9) | 0.5 | (0.2-1.5) |
| X-X-0301 | 125 | (24.9) | 132 | (26.9) | 1.3 | (0.9-1.7) | 140 | (26.1) | 1.2 | (0.9-1.6) | 167 | (26.2) | 126 | (29.7) | 1.4 | (1.0-1.9) |
| 0702-0702-X | 101 | (20.1) | 82 | (16.7) | 1.0 | (0.7-1.4) | 115 | (21.4) | 1.2 | (0.9-1.7) | 117 | (18.4) | 80 | (18.9) | 1.3 | (0.9-1.8) |
| 0702-X-0301 | 0 | (0.0) | 5 | (1.0) | -- | 1 | (0.2) | -- | 1 | (0.2) | 0 | (0.0) | -- | |||
| X-0702-0301 | 4 | (0.8) | 6 | (1.2) | 1.2 | (0.3-4.4) | 6 | (1.1) | 1.3 | (0.3-4.7) | 5 | (0.8) | 0 | (0.0) | -- | |
| 0702-0702-0301 | 24 | (4.8) | 53 | (10.8) | 2.7 | (1.6-4.6)* | 37 | (6.9) | 1.7 | (1.0-2.9) | 33 | (5.2) | 50 | (11.8) | 2.8 | (1.7-4.5)* |
| B*0801-DRB1*0301-DQB1*0201 | ||||||||||||||||
| X-X-X | 346 | (69.9) | 379 | (77.8) | ref | 396 | (74.0) | ref | 450 | (71.2) | 321 | (76.4) | ref | |||
| 0801-X-X | 25 | (5.1) | 15 | (3.1) | 0.6 | (0.3-1.1) | 21 | (3.9) | 0.7 | (0.4-1.4) | 30 | (4.7) | 23 | (5.5) | 1.1 | (0.6-1.9) |
| X-0301-X | 0 | (0.0) | 0 | (0.0) | -- | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |||||
| X-X-0201 | 0 | (0.0) | 0 | (0.0) | -- | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |||||
| 0801-0301-X | 1 | (0.2) | 1 | (0.2) | 0.7 | (0.0-11.3) | 0 | (0.0) | 1 | (0.2) | 1 | (0.2) | 1.4 | (0.1-22.2) | ||
| 0801-X-0201 | 0 | (0.0) | 0 | (0.0) | -- | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |||||
| X-0301-0201 | 29 | (5.9) | 16 | (3.3) | 0.5 | (0.3-1.0) | 26 | (4.9) | 0.8 | (0.5-1.4) | 36 | (5.7) | 23 | (5.5) | 0.9 | (0.5-1.5) |
| 0801-0301-0201 | 97 | (19.6) | 73 | (15.0) | 0.7 | (0.5-1.0) | 92 | (17.2) | 0.8 | (0.6-1.2) | 115 | (18.2) | 52 | (12.4) | 0.6 | (0.4-0.9) |
| DRB1*13-DQB1*06 | ||||||||||||||||
| X-X | 60 | (10.1) | 61 | (16.1) | ref | 58 | 12.7 | ref | 70 | (11.7) | 54 | (14.2) | ref | |||
| DRB1*13-X | 2 | (0.3) | 0 | (0.0) | 0 | 0 | 3 | (0.5) | 0 | (0.0) | ||||||
| X-DQB1*06 | 77 | (12.9) | 71 | (18.7) | 0.9 | (0.6-1.4) | 77 | 16.8 | 1.1 | (0.7-1.7) | 84 | (14.1) | 73 | (19.3) | 1.1 | (0.7-1.8) |
| X-DQB1*0301 | 71 | (11.9) | 101 | (26.6) | 1.4 | (0.9-2.2) | 87 | 19 | 1.2 | (0.8-2.0) | 91 | (15.2) | 68 | (17.9) | 1.0 | (0.6-1.5) |
| X-DQB1*0302 | 56 | (9.4) | 50 | (13.2) | 0.9 | (0.5-1.5) | 52 | 11.4 | 1.0 | (0.6-1.7) | 65 | (10.9) | 46 | (12.1) | 0.9 | (0.5-1.5) |
| X-DQB1*0501 | 44 | (7.4) | 38 | (10.0) | 0.9 | (0.5-1.5) | 47 | 10.3 | 1.1 | (0.6-1.9) | 54 | (9.0) | 14 | (3.7) | 0.3 | (0.2-0.7)* |
| DRB1*13-DQB1*06 | 61 | (10.2) | 34 | (9.0) | 0.6 | (0.3-1.0) | 35 | 7.6 | 0.6 | (0.3-1.0) | 77 | (12.9) | 25 | (6.6) | 0.4 | (0.2-0.7)* |
| DRB1*13-DQB1*0301 | 7 | (1.2) | 9 | (2.4) | 1.4 | (0.5-3.9) | 2 | 0.4 | 0.3 | (0.1-1.6) | 7 | (1.2) | 7 | (1.8) | 1.3 | (0.4-3.9) |
| DRB1*13-DQB1*0302 | 1 | (0.2) | 1 | (0.3) | 0.7 | (0.0-12.2) | 0 | 0 | 1 | (0.2) | 0 | (0.0) | ||||
| DRB1*13-DQB1*0501 | 0 | (0.0) | 0 | (0.0) | 1 | 0.2 | 0 | (0.0) | (0.0) | |||||||
| DRB1*13-DQB1*06/*0301 | 52 | (8.7) | 56 | (14.8) | 1.1 | (0.6-1.8) | 37 | 8.1 | 0.8 | (0.4-1.3) | 70 | (11.7) | 58 | (15.3) | 1.1 | (0.6-1.7) |
| DRB1*13-DQB1*06/*0302 | 30 | (5.0) | 29 | (7.7) | 1.0 | (0.5-1.8) | 37 | 8.1 | 1.3 | (0.7-2.4) | 42 | (7.0) | 23 | (6.1) | 0.7 | (0.4-1.3) |
| DRB1*13-DQB1*06/*0501 | 23 | (3.9) | 24 | (6.3) | 1.0 | (0.5-2.1) | 25 | 5.5 | 1.2 | (0.6-2.3) | 33 | (5.5) | 11 | (2.9) | 0.4 | (0.2-0.9) |
1
Odds ratios are adjusted for race. Bolding represents significant associations, although rounding sometimes caused confidence intervals to include 1.0.
2
Controls for the vulvar cancer study include women with a history of hysterectomy.
*
Holm test p-value < 0.05, result is significant after adjusting for multiple comparisons.