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. Author manuscript; available in PMC: 2009 Mar 30.
Published in final edited form as: CNS Neurol Disord Drug Targets. 2008 Apr;7(2):129–143. doi: 10.2174/187152708784083821

Figure 1. CNS DISORDERS ARE COMPLEX PSYCHIATRIC CONDITIONS.

Figure 1

Multiple factors predispose the developing and adult CNS to disease. This axis includes defects in glutamatergic and GABAergic neurotransmission, neuromodulation by other transmitter systems such as dopaminergic and cholinergic, genetic and epigenetic factors. Although the contribution of each predisposing factor may vary depending on the disease state, in most cases, all can negatively impact the prognosis.