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Impaired lymphocyte development in RAG1-S723C homozygous mice. Flow cytometric analyses were performed on RAG1+/+, RAG1+/S723C, and RAG1S723C/S723C littermates, as indicated, at 5 weeks of age. (A) Thymocytes and lymph node cells were stained with αCD4 and αCD8 antibodies. (B) Bone marrow and splenocytes were stained with antibodies against the indicated cell-surface markers.
