Table 1.

Parameters used for the equations. Rates are calculated from the catalytic rates and/or the dissociation constants (K_D) reported in the literature. For additional information see supplement, section I.

k1	k−1	k2	k−2	${\text{k}}_3^{\text{cat}}$	K3m	${\text{k}}_4^{\text{cat}}$	K4m	${\text{k}}_5^{\text{cat}}$	K5m
1.8×10−4 (μm)3(mols)−1s−1	3.0 s−1	1.7×10−4 (μm)3(mols)−1s−1	0.4 s−1	0.038 s−1	1.64×103 (mols)/(μm)3	0.003 s−1	9.12×103 (mols)/(μm)3	0.1 s−1	1.07×102 (mols)/(μm)3
Sonderman et al. Cell (2004)	Sonderman et al. Cell (2004)	Sonderman et al. Cell (2004)	Sonderman et al. Cell (2004)	Freedman et al. PNAS (2006)	Sonderman et al. Cell (2004) Freedman et al. PNAS (2006)	Boykevisch et al. Curr. Biol. (2006)	Sonderman et al. Cell (2004) Boykevisch et al. Curr. Biol. (2006)	Gideon et al. Mol. Cell. Biol. (1992) Trahey at al. Science (1987)	Gideon et al. Mol. Cell. Biol. (1992) Trahey at al. Science (1987)