TABLE 1.
No TBI (N = 2436) |
TBI (N = 3870) |
||||
---|---|---|---|---|---|
No. | % | No. | % | ||
Sex | |||||
Female | 1227 | 50.4% | 1622 | 41.9% | |
Male | 1209 | 49.6% | 2248 | 58.1% | |
Race | |||||
White | 2154 | 88.4% | 3512 | 90.8% | |
Non-white | 282 | 11.6% | 358 | 9.2% | |
Age at HCT (years) | |||||
0–17 | 376 | 15.4% | 1006 | 26.0% | |
18–44 | 1023 | 42.0% | 2194 | 56.7% | |
45–65 | 1037 | 42.6% | 670 | 17.3% | |
Year of HCT | |||||
1969–1975 | 34 | 1.4% | 68 | 1.8% | |
1976–1980 | 88 | 3.6% | 308 | 8.0% | |
1981–1985 | 83 | 3.4% | 630 | 16.3% | |
1986–1990 | 226 | 9.3% | 887 | 22.9% | |
1991–1995 | 532 | 21.8% | 916 | 23.7% | |
1996–2000 | 645 | 26.5% | 693 | 17.9% | |
2001–2005 | 828 | 34.0% | 368 | 9.5% | |
Cell source | |||||
Autologous | 924 | 37.9% | 502 | 13.0% | |
Matched related donor | 1070 | 43.9% | 1843 | 47.6% | |
Mismatched related donor | 75 | 3.1% | 477 | 12.3% | |
Matched unrelated donor | 322 | 13.2% | 1029 | 26.6% | |
Unknown | 45 | 1.8% | 19 | 0.5% | |
AGVHD | |||||
Grade 0–1 | 1454 | 59.7% | 1274 | 32.9% | |
Grade 2–4 | 982 | 40.3% | 2596 | 67.1% | |
Clinical extensive CGVHD | |||||
No | 1660 | 68.1% | 2221 | 57.4% | |
Yes | 776 | 31.9% | 1649 | 42.6% | |
Prior exposure to radiation therapy |
|||||
Probably not exposed | 1041 | 42.7% | 2290 | 59.2% | |
Possibly not exposed | 488 | 20.0% | 118 | 3.1% | |
Possibly exposed | 347 | 14.2% | 496 | 12.8% | |
Probably exposed | 560 | 23.0% | 966 | 25.0% | |
Mean | Min–Max | Mean | Min–Max | ||
Age at HCT (years) | 38.1 | 0.3–65 | 28.8 | 0.5–65 | |
Duration of follow-up (years) | 5.8 | 0.3–33.1 | 6.6 | 0.3–36.2 |
Abbreviations: AGVHD, acute graft-versus-host disease, CGVHD, chronic graft-versus-host disease; HCT, hematopoietic cell transplantation; TBI, transplant population irradiated as part of conditioning regimen.