Table 2.

Association of ε4 Allele Status with Level and Change in Motor Function^*

Model Terms	Estimate	S.E.	p-Value
Time	−0.028	0.005	p<0.001
Age	−0.031	0.003	p<0.001
Age × Time	−0.003	0.001	p<0.001
Sex	0.324	0.042	p<0.001
Sex × Time	−0.028	0.009	p=0.003
Education	0.029	0.006	p<0.001
Education × Time	0.001	0.001	p=0.469
ε4 Allele Status	0.026	0.041	p=0.532
ε4 Allele Status × Time	−0.027	0.012	p=0.025

^*Estimated from a generalized estimating equation model with global motor function as the outcome; including a term for motor decline, Time (in years since baseline). The model terms Age at baseline (centered at 80 years), Sex (coded as “1” for men, “0” for women), Education (number of years) and ε4 allele status show the cross sectional relationships between these terms and level of global motor function at baseline. In addition, the model also included terms for age at baseline, sex, and education, ε4 allele status and their interactions with motor decline (Time). Results show that age at baseline, sex and the presence of ε4 allele are all associated with more rapid motor decline (negative estimate).