Table 3.
Presence of ε4 Allele, Other Covariates and the Rate of Change in Motor Function*
| Variable | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 |
|---|---|---|---|---|---|---|
| Time | −0.023 (0.006, p<0.001) | −0.029 (0.005, p<0.001) | −0.029 (0.006, p<0.001) | −0.024 (0.008, p=0.003) | −0.030 (0.006, p<0.001) | −0.022 (0.009, p=0.011) |
| ε4 Allele Status | 0.050 (0.040, p=0.221) | 0.001 (0.039, p=0.971) | 0.002 (0.038, p=0.963) | 0.014 (0.040, p=0.726) | 0.016 (0.041, p=0.695) | 0.008 (0.038, p=0.842) |
| ε4 Allele Status × Time | −0.025 (0.012, p=0.035) | −0.028 (0.012, p=0.019) | −0.028 (0.012, p=0.019) | −0.027 (0.012, p=0.026) | −0.026 (0.012, p=0.031) | −0.025 (0.012, p=0.040) |
| Cognitive Status | −0.202 (0.042, p<0.001) | −0.180 (0.037, p<0.001) | ||||
| Cognitive Status × Time | −0.021 (0.010, p=0.038) | −0.023 (0.010, p=0.025) | ||||
| BMI | −0.014 (0.003, p<0.001) | −0.011 (0.004, p=0.007) | −0.011 (0.004, p=0.007) | |||
| BMI × Time | −0.001 (0.001, p=0.192) | −0.001 (0.001, p=0.355) | −0.001 (0.001, p=0.199) | |||
| BMI*BMI | −0.000 (0.000, p=0.457) | −0.000 (0.000, p=0.574) | ||||
| BMI*BMI × Time | −0.000 (0.000, p=0.968) | 0.000 (0.000, p=0.411) | ||||
| Vascular Risks | −0.080 (0.021, p<0.001) | −0.057 (0.021, p=0.007) | ||||
| Vascular Risks × Time | −0.005 (0.005, p=0.331) | −0.007 (0.006, p=0.218) | ||||
| Vascular Diseases | −0.106 (0.027, p<0.001) | −0.076 (0.026, p=0.003) | ||||
| Vascular Diseases × Time | 0.008 (0.007, p=0.253) | 0.013 (0.007, p=0.091) |
Estimated from a generalized estimating equation model with global motor function as the outcome; including a term for motor decline, Time (in years since baseline). All models controlled for age at baseline (centered at 80 years), Sex (coded as “1” for men, “0” for women), and education (number of years) [terms not shown]. ε4 allele status and various covariates show the cross sectional relationships between these terms and level of global motor function at baseline. In addition, the model also included terms for ε4 allele status and covariates and their interactions with motor decline (Time). Results show that the presence of ε4 allele is associated with more rapid motor decline (negative estimate) even after controlling for cognitive status, body composition, vascular risk factors and diseases.