TABLE 1.
Effect of copper on the steady-state levels of MT and proto-oncogene mRNAs.
| Exposure Time (h) |
|||
|---|---|---|---|
| Gene | 0 | 4 | 24 |
| MT-1 | 1.00 +/− 0.62 | 3.51 +/− 0.53* | 1.73 +/− 0.60 |
| c-fos | 1.00 +/− 0.96 | 28.84 +/− 7.06* | 2.08 +/− 0.91 |
| c-jun | 1.00 +/− 0.46 | 30.48 +/− 5.73* | 8.82 +/− 2.09 |
| c-myc | 1.00 +/− 0.66 | 16.22 +/− 2.02* | 2.06 +/− 0.53 |
COS-7 cells were exposed to 400 ìM copper for 0, 4 or 24 h. Differences in mRNA expression were detected by Real Time RT-PCR.
*
indicates significantly different from untreated cells by ANOVA, p<0.05, n=3 observations.