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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jan 22;29(4):488–494. doi: 10.1161/ATVBAHA.108.183392

Figure 3. Effects of arginase inhibition on DNA synthesis, p21 protein expression, apoptosis and endothelial regrowth after rat carotid artery balloon injury.

Figure 3

A. Representative immunostaining for PCNA (shown in red) in injured carotid arteries 2 days post-injury. B. PCNA labeling index (LI) in the media at 2, 7, and 14 days post-injury. C. PCNA LI in the neointima at 7 and 14 days post-injury. D. Western blot of p21 protein in injured carotid arteries 2 days post-injury. E. TUNEL LI two days post-injury. F. Reendothelialization of carotid arteries 14 days post-injury. Arteries were treated topically with an empty gel, or with gel containing BEC (1mg) or L-OHNA (1mg) immediately after injury. Results are mean ± SEM of 4–6 experiments. *Statistically significant effect of BEC or L-OHNA.