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. Author manuscript; available in PMC: 2009 Sep 12.
Published in final edited form as: Oncogene. 2009 Jan 19;28(10):1339–1347. doi: 10.1038/onc.2008.480

Fig. 5. Effect of GRIM-19 on v-Src-dependent cell motility.

Fig. 5

(A) Injury-induced migration of cells into the wounded area was monitored. Magnification: 100×. White line indicates the edge of injured site. Note the rapid migration of v-Src-expressing cells, but not the controls, into the wounded area. The wildtype and mutant GRIM-19 proteins were expressed using lentiviral vectors and their impact on cell motility was measured. Note suppression of v-Src-induced cell motility in the presence of wildtype GRIM-19. The mutant proteins have lost such suppressive activity to varying degrees. (B) A quantified view of the inhibitory effects of GRIM-19 on cell motility. Distance migrated from the edge of the monolayer to the center of the denuded area 4h after the induction of injury was calculated from a number of independent samples (n=8) and plotted.