Skip to main content
. Author manuscript; available in PMC: 2009 Mar 30.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Jul;32(7):1260–1270. doi: 10.1111/j.1530-0277.2008.00681.x

Fig. 1.

Fig. 1

Effects of exposure to the A1 antagonist DPCPX or co-exposure to DPCPX and the A1 agonist CCPA on neurotoxicity in male and female organotypic hippocampal slice cultures during 24 hours of withdrawal from 10 days of ethanol exposure (43.1 to 26.9 mM). Exposure to DPCPX during ethanol withdrawal (EWD) produced significant sex-dependent toxicity in CA1 pyramidal cells of female cultures and sex-independent toxicity CA3 pyramidal cells and dentate granule cells, effects that were prevented by co-exposure to CCPA. *p < 0.01 versus female controls and ethanol withdrawn slices; **p < 0.01 versus all other groups, including male cultures treated with DPCPX during ethanol withdrawal; #p < 0.05 versus females cultures exposed to DPCPX during ethanol withdrawal. ##p < 0.05 versus EWD+DPCPX.