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. 2008 Dec 3;28(49):13285–13295. doi: 10.1523/JNEUROSCI.4393-08.2008

Figure 1.

Figure 1.

Different accumulations of mutant htt in neuronal versus glial cells in HD mouse brains. A, EM48 immunohistochemical staining of the striatum (Str) and white matter (WM) of the corpus callosum of wild-type (WT) and HD150Q knock-in (KI) mice at 15 months of age. Note that EM48 labels more neuronal cells in the striatum than glial cells in the corpus callosum. B, EM48 immunohistochemical staining of an R6/2 mouse brain that expresses exon1 mutant htt. Glial cells in the white matter (WM) of the corpus callosum and in neuronal cells of the striatum (Str) show different extents of mutant htt accumulation. The mouse was examined at the age of 12 weeks. Scale bars, 10 μm.