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. 2009 Apr 10;5(4):e1000372. doi: 10.1371/journal.ppat.1000372

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Co-receptor usage of viruses in ND macaques and parental SIV strains was analyzed using CCR5 and CXCR4 antagonists, TAK779 and AMD3100, respectively. TZM-bl cells were incubated with pseudotyped viruses in the absence or presence of the designated concentration of antagonist. The mean percentage of the control luciferase activity is shown with standard errors. Pseudotyped viruses were prepared using Env of SIVsmH635FC and SIVsmE543-2, and two Env clones each from H704 and H709. The infection with pseudotyped viruses with Env from H704 and H709 were inhibited by TAK779, but not AMD3100, similar to parental SIVsmH635FC and SIVsmE543-3. In contrast, the X4-tropic HIV-1NL43-3 was inhibited by AMD3100, but not TAK779.