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. 2006 Jan 19;173(9):999–1007. doi: 10.1164/rccm.200411-1507OC

Figure 8.

Figure 8.

(A) Superoxide dismutase (SOD) activity of cardiac ventricular homogenates as a percentage of similar measurements made in matching control animals at 4 h post-treatment for all treatment groups (values represent means ± SEM). Relative to control animals, LPS treatment alone was associated with reduced MnSOD activity and increased total SOD activity in the ventricular tissue (*p < 0.05 vs. matching control), indicating that SOD activity was selectively reduced in the mitochondrial compartment. Pretreatment with either CsA or FK506 resulted in significantly increased activities for both the total tissue SOD (*p < 0.05 vs. matching control) and MnSOD (†p < 0.05 vs. matching control and LPS-treated alone). (B) Relative protein expression and nitration of MnSOD in cardiac ventricular homogenates at 4 h post-treatment for all treatment groups (values represent means ± SEM). Significantly decreased relative tissue expression (normalized to actin) and notably increased nitration of MnSOD were demonstrated in the ventricular tissue after LPS treatment alone (*p < 0.05 vs. matching control). By contrast, relative tissue MnSOD expression was dramatically increased and MnSOD nitration significantly reduced in both groups receiving calcineurin inhibitor pretreatment (†p < 0.01 vs. matching control and LPS-treated alone).