TABLE 2.
NONTYPEABLE Haemophilus influenzae ANTIGEN INDUCTION OF HUMAN ALVEOLAR AND BLOOD MACROPHAGE TNF-α*
| LOS | P6 | P2 | Total OM | |
|---|---|---|---|---|
| Alveolar macrophages | ||||
| Group 1† | 71.5 (619.6)‡§ | 107.0 (367.0)‡§ | 3.3 (10.0) | 32.3 (34.4)§ |
| Group 2 | 332.4 (688.5) | 546.0 (826.4) | 5.5 (3.5) | 123.5 (231.1) |
| Group 3 | 990.9 (1728.5) | 1,147.5 (1,406.1) | 10.4 (17.9) | 657.6 (1,070.5) |
| Kruskal-Wallis p value | 0.006 | 0.028 | 0.35 | 0.039 |
| Blood macrophages | ||||
| Group 1 | 694.0 (1,539.0) | 956.9 (1,514.5) | 16.0 (116.3) | 918.8 (1,811.8) |
| Group 2 | 493.6 (1,357.8) | 777.5 (824.3) | 36.3 (97.2) | 634.3 (1,320.6) |
| Group 3 | 989.7 (1,209.3) | 1,070.3 (1,379.8) | 54.0 (179.1) | 1,028.5 (876.2) |
| Kruskal-Wallis p value | 0.26 | 0.35 | 0.33 | 0.59 |
Definition of abbreviations: LOS = lipooligosaccharide; OM = outer membrane.
*
Alveolar and blood macrophages of each donor were treated with 0.1 μg/ml of each nontypeable H. influenzae antigen. Values correspond with data in Figure 2. Each value is expressed as median pg/ml (interquartile range).
†
Group 1, chronic obstructive pulmonary disease; Group 2, exsmokers; Group 3, nonsmokers.
‡
p < 0.05, Group 1 versus Group 2 by Mann Whitney U rank test.
¶p < 0.05, Group 1 versus Group 3 by Mann Whitney U rank test.