TABLE 3.
NONTYPEABLE Haemophilus influenzae ANTIGEN INDUCTION OF HUMAN ALVEOLAR AND BLOOD MACROPHAGE IL-8*
| LOS | P6 | p2 | Total OM | |
|---|---|---|---|---|
| Alveolar macrophages | ||||
| Group 1† | 3271.9 (6893.1)‡ | 6,781.9 (7,286.6) | 857.7 (2,105.7) | 2,268.6 (5,594.1) |
| Group 2 | 9229.8 (30057.6) | 24,832.6 (40,906.2) | 1,851.8 (1,187.9) | 7,126.9 (8,754.1) |
| Group 3 | 2028.5 (18749) | 2,184.5 (27,430.6) | 1,738.6 (1,351.1) | 2,334.7 (3,730) |
| Kruskal Wallis p value | 0.029 | 0.3 | 0.76 | 0.22 |
| Blood macrophages | ||||
| Group 1 | 9,685.3 (13,500.2) | 16,424.2 (37,274.9) | 2,415.3 (2,987.8) | 10,339.1 (21,597.6) |
| Group 2 | 8,354.7 (21,933.6) | 16,469.4 (27,022.6) | 2,347.2 (9,513.4) | 4,924.9 (19,710.1) |
| Group 3 | 5,098.7 (22,403.3) | 4,897.2 (25,556.2) | 2,085.0 (4,119.7) | 4,619.7 (5,122.6) |
| Kruskal Wallis p value | 0.65 | 0.25 | 0.85 | 0.13 |
Definition of abbreviations: LOS = lipooligosaccharide; OM = outer membrane.
*
Alveolar and blood macrophages of each donor were treated with 0.1 μg/ml of each nontypeable H. influenzae antigen. Values correspond with data in Figure 1. Each value is expressed as median pg/ml (interquartile range).
†
Group 1, chronic obstructive pulmonary disease; Group 2, exsmokers; Group 3, nonsmokers.
‡
p < 0.05, Group 1 versus Group 2 by Mann Whitney U rank test.