TABLE 6.

NONTYPEABLE Haemophilus influenzae ANTIGEN INDUCTION OF HUMAN ALVEOLAR AND BLOOD MACROPHAGE IL-10^*

	LOS	P6	P2	Total OM
Alveolar macrophages
Group 1†	2.1 (8.7)‡§	0.0 (0.0)	0.0 (0.0)	0.0 (34.3)‡§
Group 2	12.1 (51.4)	0.2 (2.0)	0.1 (2.6)	26.4 (52.8)
Group 3	32.2 (58.1)	0.0 (0.2)	0.0 (0.7)	81.0 (138.3)
Kruskal Wallis p value	0.002	—‖	—‖	0.0009
Blood macrophages
Group 1	438.4 (887.7)	5.0 (9.2)	45.1 (65.6)	859.0 (1,393.7)
Group 2	400.2 (796)	1.0 (4.5)	45.5 (167.7)	470.4 (1,513.5)
Group 3	180.9 (257.9)	1.7 (2.5)	36.1 (79.6)	453.4 (569.6)
Kruskal Wallis p value	0.45	0.06	0.62	0.56

Definition of abbreviations: LOS = lipooligosaccharide; OM = outer membrane.

^*Alveolar and blood macrophages of each donor were treated with 1 μg/ml of each nontypeable H. influenzae antigen. Values correspond with data in Figure 5. Each value is expressed as median pg/ml (interquartile range).

^†Group 1, chronic obstructive pulmonary disease; Group 2, exsmokers; Group 3, nonsmokers.

^‡p < 0.05, Group 1 versus Group 2 by Mann Whitney U rank test.

^§p < 0.05, Group 1 versus Group 3 by Mann Whitney U rank test.

^‖p < 0.05, but values were considered too low for biological significance.