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. 2006 Mar 30;174(1):75–83. doi: 10.1164/rccm.200511-1784OC

Figure 1.

Figure 1.

Thymic histopathology from preterm baboons given O2 pro re nada (PRN) ± anti-bombesin antibody 2A11. (a–c) Hematoxylin and eosin–stained sections of thymus from 125-d/PRN animals. Scale bar in lower left corner = 500 μm. (a) Bronchopulmonary dysplasia (BPD) control 125-d/PRN × 14-d animal, no intervention (n = 10). (b) Image shows thymus from a 125-d/PRN × 14 d animal treated with MOPC21 (negative control IgG) (n = 6). (c) Image shows thymus from a 125-d/PRN × 14 d animal treated with 2A11 (n = 5). (d and e) Quantitative morphometric analysis for volume percent of thymic cortex on the entire slide expressed as a percentage of the total thymic tissue volume (cortex + medulla). (d) Bar graph shows 125-d/PRN: groups include: 125-d/PRN × 21 d with no intervention (n = 5); and 125-d/PRN × 21 d + 2A11 (n = 5). *p = 0.004 compared with 125-d/PRN + MOPC; †p = 0.001 compared with 125-d/PRN × 14 d with no intervention; **p = 0.03 compared with 125-d/PRN × 21 d with no intervention. (e) Gestational control animals (GCs): 125 d (n = 4); 140 d (n = 5); 175 d (n = 3); and full-term natural delivery (n = 3). p Values compared with 125-d GCs: *p < 0.001; †p < 0.0001.