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. 2006 Mar 30;174(1):75–83. doi: 10.1164/rccm.200511-1784OC

Figure 3.

Figure 3.

Proliferating cell nuclear antigen (PCNA)–immunostaining of thymuses from 125-d/PRN baboons ± 2A11. (a and b) PCNA-immunostained sections of thymus from 125-d/PRN animals. Scale bar in lower left corner = 50 μm. Arrows indicate thymic cortex (capsule). (a) BPD control 125-d/PRN × 21-d animal, no intervention (n = 3). (b) Image shows 125-d/PRN × 21 d treated with 2A11 (n = 6). (c and d) Quantitative analysis for numbers of PCNA+ nuclei/in2 of thymic cortex tissue. Similar results were obtained when numbers of PCNA+ cells were normalized for the area of the cortex plus medulla. Groups tested were: (c) 125-d/PRN × 14-d animal, no intervention (n = 6); 125-d/PRN × 14 d + MOPC21 (n = 6); 125-d/PRN × 14 d + 2A11 (n = 4); *p < 0.0001 compared with 125-d/PRN × 21 d with no intervention. (d) GCs for PCNA+ nuclei/in2 of thymic cortex tissue section: 125 d (n = 4); 140 d (n = 4); 175 d (n = 3); and full-term natural delivery (n = 3). p Value compared with 125-d GCs: *p < 0.001. M = medulla.