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. 2006 Mar 30;174(1):75–83. doi: 10.1164/rccm.200511-1784OC

Figure 4.

Figure 4.

CD4 and CD8 immunostaining of thymuses from 125-d/PRN baboons. (a–d) Immunostained sections of thymus from 125-d/PRN animals. Scale bar in lower left corner = 50 μm. Arrowheads indicate thymic cortex (capsule). (a) CD4-immunostaining of thymus from one representative control 125-d/PRN × 14-d animal (n = 3). (b) CD4 immunostaining of thymus from one representative 125-d/PRN × 14-d animal treated with 2A11 (n = 3). (c) CD8 immunostaining of thymus from one representative control 125-d/PRN × 14-d animal (n = 5). (d) CD8 immunostaining of thymus from one representative 125-d/PRN × 14-d animal treated with 2A11 (n = 3). (e) Quantitative morphometric analysis for numbers of CD+ cells per total area of each thymic tissue field (4 fields/animal). Groups tested were: 125-d/PRN × 14-d animals, no intervention (n = 5); 125-d/PRN × 14 d + MOPC21 (n = 6); 125-d/PRN × 14 d + 2A11 (n = 3); 125-d/PRN × 21 d, no intervention (n = 3); 125-d/PRN × 21 d + 2A11 (n = 5); *p < 0.0005; †p < 0.0025 compared with 125-d/PRN × 14 d with no intervention. *p < 0.002, †p < 0.04 compared with MOPC-treated 125-d/PRN group. M = medulla.