Table 1.
List of differentially-expressed proteins from the lens and vitreous of P1 and P16 mice.
| Protein up-regulated in P1 (PI 4–7) | ||||
| Swisspro ID | NCBI GI # | Protein | Molecular weight (kDa) | Biological Process |
| Q8CGQ2 | 27923590 | A disintegrin and metalloprotease domain 4 | 84.4 | Protein metabolism |
| Q5XJY5 | 52789310 | Archain | 57.2 | Protein transport |
| P70327 | 6755722 | T-box transcription factor TBX6 | 58.6 | Transcription regulation |
| Q60803 | U33840 | Tnf receptor-associated factor 3 | 64.2 | Apoptosis |
| Q8WLM9 | AAH21760 | H2-T10 protein | 43 | Antigen processing and presentation |
| P15092 | 14714795 | Ifi204 protein | 71.6 | Transcription regulation |
| O08760 | 2197093 | N-glycosylase/DNA lyase | 38.8 | DNA repair |
| Q9JIL4 | AAH13512 | PDZ domain containing 1 | 56 | Protein binding |
| A2ANU5 | NP_075755 | Zinc finger protein 120 | 15 | Regulation of transcription |
| Q91WU6 | NP_598728 | Palmitoyltransferase ZDHHC7 | 35 | Protein palmitoylation mitochondrial |
| Q99L13 | 21704140 | 3-hydroxyisobutyrate dehydrogenase, | 35 | |
| Q9R1P4 | AAH05762 | Proteasome subunit alpha type-1 | 29.5 | Protein metabolism |
| Q8R1C9 | NP_666197 | Amyloid beta (A4) precursor protein-binding, family B, member 3 | 52.6 | Negative regulation of apoptosis |
| Q5D0F3 | AAH24897 | Tap1 protein | 63.4 | Defense response |
| Q8BTW3 | NP_082550 | Exosome complex exonuclease MTR3 | 28.3 | rRNA processing |
| P63158 | CAA56631 | High mobility group protein B1 | 28.3 | Transport |
| Q8VED5 | 17512384 | Keratin, type II cytoskeletal 79 | 57.5 | Structural molecule activity |
| Q6P904 | 38173917 | D430015B01Rik protein | 72 | Unclassified |
| P21126 | XP_356994 | Ubiquitin-like protein 4A | 17.8 | Protein metabolism |
| Q60872 | AF026481 | Eukaryotic translation initiation factor 1A | Protein synthesis | |
| O88569 | AAH59107 | Heterogeneous nuclear ribonucleoproteins A2/B1 | 37.4 | mRNA processing |
| B1AZ15 | NP_795999 | Cobl-related 1 | 133 | neural tube formation |
| Q923J1 | AY032951 | Transient receptor potential cation channel subfamily M member 7 Also known as: | 212 | Cation transport |
| Q91YM8 | NP_033129 | Ribonucleoside-diphosphate reductase | 90 | DNA replication |
| Q8CIE6 | AAH47429 | Coatomer subunit alpha | 138 | Protein transport |
| Q8BNA6 | XP_146821 | Similar to fat3; fat3 protein | 502 | Cell adhesion |
| Q811W1 | NP_780712 | Alanine and arginine rich domain containing protein | 18.9 | Unclassified |
| Q8BW70 | AAH57122 | Ubiquitin carboxyl-terminal hydrolase 38 | 116 | Ubl conjugation pathway |
| Q2KHS8 | NP_473422 | Mta1 protein | 79.4 | Cancer progression |
| Q60668 | AAH49098 | Heterogeneous nuclear ribonucleoprotein D0 | 38.3 | DNA binding |
| P16858 | AK002273 | Glyceraldehyde-3-phosphate dehydrogenase | 35.8 | Glucose metabolism |
| Q80ZS8 | AAH48503 | DiGeorge syndrome critical region gene 6 | 22.8 | Development |
| P15105 | NP_032157 | Glutamine synthetase | 42 | Glutamate metabolism |
| Q02789 | L06234 | Voltage-dependent L-type calcium channel subunit alpha-1S | 213 | Ion transport |
| Q6PB52 | AAH59887 | Lrpap1 protein | 35.4 | Chaperone |
| Q80XR6 | AAH43069 | Hnrpab protein (Heterogeneous nuclear ribonucleoprotein A/B) | 33.8 | DNA binding |
| O08749 | NP_031887 | Dihydrolipoyl dehydrogenase, mitochondrial precursor | 54.2 | mitochondrial electron transport |
| Q61414 | AAH57934 | Keratin, type I cytoskeletal 15 | 49 | Cytoskeletal |
| Q02257 | AAH40757 | Junction plakoglobin | 81.8 | Cell adhesion |
| O35098 | NP_036123 | Dihydropyrimidinase-related protein 4 | 61.9 | axon growth |
| P80317 | NP_033968 | T-complex protein 1 subunit zeta | 58 | Chaperone |
| Q8R081 | 20072624 | Heterogeneous nuclear ribonucleoprotein L | 60 | RNA synthesis/degradation |
| Q8VEI1 | AAH18459 | Cct6a protein | 42.9 | Protein metabolism |
| Q62420 | 10720274 | Endophilin-A1 | 40 | Unclassified |
| Q61183 | NP_035242 | Poly (A) polymerase alpha | 82.3 | RNA synthesis |
| Q6PGC1 | AAH57112 | Putative ATP-dependent RNA helicase DHX29 | 153.9 | RNA helicase |
| Q6A085 | BC035547 | Zinc finger protein 629 | 96 | DNA binding |
| Q9CWJ9 | AAH39925 | Bifunctional purine biosynthesis protein PURH | 64.2 | Purine nucleotide biosynthesis |
| Q60864 | NP_058017 | Stress-induced phosphoprotein 1 | 62.5 | Chaperone |
| Q8BUU7 | NP_780363 | N-Acetylgalactosamine kinase | 49.3 | Galactose metabolism |
| Q9QXL1 | AF202893 | Kinesin-like protein KIF21B | 186 | Motor protein |
| Q9Z0T6 | AF116459 | Polycystic kidney disease and receptor for egg jelly-like protein | 241 | Ion transport |
| Q3TNZ7 | NP_031756 | Procollagen, type XII, alpha 1 | 70 | Extracellualr matrix |
| Q07E15 | DP000183 | Cortactin-binding protein | 178 | Cytoskeleton organization |
| Q9WU62 | AF117610 | Inner centromere protein | 101 | Cell cycle |
| Q7SIG6 | BC096022 | Development and differentiation-enhancing factor 2 | 106 | GTPase activation |
| Q8VCW4 | AAH18388 | Unc93 homolog B | 67 | Antigen presentation |
| Protein up-regulated in P16 (PI 4–7) | ||||
| Swisspro ID | NCBI GI # | Protein | Molecular weight (kDa) | Biological Process |
| Q9ESS2 | AB036765 | Fibroblast growth factor 22 | 18.9 | Growth factor |
| Q6PAC1 | AAH60377 | Gsn protein | 80.7 | Vesicle-mediated transport |
| Q3UGX3 | AK147307 | N-acetyltransferase 8-like protein | 32.7 | Acyltransferase |
| Q9R1S3 | AAH21148 | GPI ethanolamine phosphate transferase 1 | 105 | phosphotransferase |
| P06804 | NP_038721 | Tumor necrosis factor alpha | 25.8 | cytokine |
| Q3UHA3 | BAC98263 | Spatacsin | 273.9 | Axon transport |
| Q6PD36 | NP_109614 | Nptxr protein | 34.9 | Synapse formation and remodeling |
| Q9Z148 | AAH58357 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | 138 | Germ cell development |
| Q8VBW1 | NP_598748 | Sodium- and chloride-dependent creatine transporter 1 | 70.9 | Ion transport |
| Q8BM14 | AK037106 | Lipase member K | 45.2 | Lipid metabolism |
| Q6P216 | BC064769 | Sytl2 protein | 59.5 | vesicular trafficking transport |
| Q99KD7 | AAH04714 | Heat shock protein 2 | 69.6 | Stress response |
| Q9DCH4 | NP_079620 | eukaryotic translation initiation factor 3, | 38 | Protein biosynthesis |
| Q91YS8 | BC014825 | Calcium/calmodulin-dependent protein kinase type 1 | 41.6 | Signal transduction |
| O08677 | AAH18158 | Kininogen-1 precursor | 73.1 | Inflammatory response |
| P28656 | NP_056596 | Nucleosome assembly protein 1-like 1 | 45.3 | modulating chromatin formation |
| P14211 | X14926 | Calreticulin | 47.9 | Cytoskeleton organization |
| Q61937 | M33212 | Nucleophosmin | 32.5 | DNA binding |
| P51859 | AAH05713 | Hepatoma-derived growth factor | 26.2 | Cellular process |
| Q5SXA9 | AAH06733 | Protein WWC1 | 124 | Protein transport |
| Q80XK0 | AAH46617 | Serine/threonine protein phosphatase | 61.4 | Hydrolase |
| Q6DD96 | NP_291068 | Protocadherin gamma subfamily A, 7 | 101.5 | Cell adhesion |
| Q8K0Z5 | AAH29186 | Tropomyosin 3, gamma | 33 | Regulation of muscle contraction |
| Q68EF4 | BC080284 | glutamate receptor, metabotropic 4 | 101.8 | Synaptic transmission |
| Q62209 | NP_035646 | Synaptonemal complex protein 1 | 115.9 | Cell cycle |
| Q9CQV8 | AF058797 | 14-3-3 protein beta/alpha | 28 | Protein targeting |
| Q8CGT7 | AAN75582 | Argonaute 5 protein | 72.1 | Enzyme |
| P97479 | U81453 | Myosin-VIIa | 254.8 | Biogenesis |
| Q792Y6 | NP_033456 | Trypsin 2 | 26 | Protease |
| Q91Z49 | NP_081502 | Putative 40-2-3 protein | 35.8 | Unclassified |
| Protein up-regulated in P1 (PI 5–8) | ||||
| Swisspro ID | NCBI GI # | Protein | Molecular weight (kDa) | Biological Process |
| Q9CQV8 | AF058797 | 14-3-3 protein beta/alpha | 28 | Protein targeting |
| P24638 | NP_031413 | Acid phosphatase 2, lysosomal | 48.5 | Biogenesis |
| Q8BGB7 | AAH21429 | Enolase-phosphatase E1 | 28.6 | Biosynthesis |
| Q810U4 | AJ543321 | Neuronal cell adhesion molecule | 138 | Cell adhesion |
| O54879 | AF022465 | High mobility group protein B3 | 23 | Regulate cell differentiation |
| Q9JIF7 | AAH30837 | Coatomer subunit beta | 107 | Vesicle-mediated transport |
| O89020 | NP_660128 | Afamin; alpha albumin; | 69.3 | transport |
| Q9CUU3 | DQ103262 | Synaptonemal complex protein 2 | 172 | Cell cycle |
| O88968 | AAH03720 | Transcobalamin 2 | 47.5 | Transport |
| Protein up-regulated in P16 (PI 5–8) | ||||
| Swisspro ID | NCBI GI # | Protein | Molecular weight (kDa) | Biological Process |
| Q6P4T0 | AAH56482 | Autophagy-related protein 2 homolog A | 210 | Unclassified |
| O88623 | NP_932760 | Ubiquitin carboxyl-terminal hydrolase 2 | 68.8 | Ubl conjugation pathway |
| Q8BK06 | AAH20074 | Fbxo9 protein | 50.7 | Ubl conjugation pathway |
| Q8CBY3 | AK034310 | leukocyte receptor cluster (LRC) member 8 | 86.7 | Unclassified |
| Q78ZA7 | NP_032698 | Nucleosome assembly protein 1-like 4 | 42.6 | Nucleosome assembly |
| Q6NVD9 | CAC83162 | Phakinin, CP49 | 45.7 | Cytoskeleton organization and biogenesis |
| O70566 | AK088648 | Diaphanous homolog 2 | 124.8 | Actin filament polymerization |
| Q6PD28 | AAH58977 | Protein phosphatase 2, regulatory subunit B (B56) | 57.3 | Signal transduction |
| O70572 | AAH10978 | Sphingomyelin phosphodiesterase 2 | 47.4 | Hydrolase |
| P49442 | AAH25072 | Inositol polyphosphate-1-phosphatase | 43.3 | Signal transduction |
| Q924W5 | NP_079971 | Structural maintenance of chromosomes protein 6 | 127.1 | DNA repair |
| Q8R2K7 | NP_899139 | snRNA-activating protein complex subunit 5 | 11.3 | Transcription |
| Q922M0 | NP_034826 | lymphocyte cytosolic protein 2 | 60.2 | Cytokine secretion |
| Q9Z0S1 | AAH11036 | Bisphosphate 3′-nucleotidase 1 | 33.1 | DNA binding |
| Q9D6R2 | AAH49956 | Isocitrate dehydrogenase 3 (NAD+) alpha | 39.6 | Tricarboxylic acid |
| P04247 | AAH25172 | Myoglobin | 17 | Transport |
| Q69ZB0 | AAH61202 | Leucine-rich repeat and coiled-coil domain-containing protein 1 | 119.1 | Unclassified |
| Protein up-regulated in P1 (PI 7–10) | ||||
| Swisspro ID | Mouse GI # | Protein | Molecular weight (kDa) | Biological Process |
| P47754 | NP_031630 | F-actin-capping protein subunit alpha-2 | 32.9 | Cytoskeleton organization |
| Q9CWS0 | NP_081269 | N(G), N(G)-dimethylarginine dimethylaminohydrolase 1 | 31.3 | hydrolase |
| O09114 | AAH38083 | Prostaglandin-H2 D-isomerase precursor | 21 | Prostaglandin biosynthesis/transport |
| Q04365 | AAA39399 | L1Md-9 repetitive sequence | 21.5 | Unclassified |
| Q9QZ09 | AJ242864 | Putative homeodomain transcription factor 1 | 86.7 | Regulation of transcription |
| Protein up-regulated in P16 (PI 7–10) | ||||
| Swisspro ID | Mouse GI # | Protein | Molecular weight (kDa) | Biological Process |
| Q9JJV0 | AAH56444 | Crystallin, beta A4 | 22.4 | Structural protein |
| P13705 | NP_034959 | MutS homolog 3 | 123 | DNA repair |
| Q8VEH2 | AAH18483 | CDKN1A interacting zinc finger protein 1 | 93.5 | mRNA splicing |