Figure 6.

Change in body weight after repeated administrations of P. aeruginosa. CF and wild-type mice were inoculated with P. aeruginosa by insufflation (arrows), and weighed daily. (A) CF (open triangles) and wild-type mice (closed circles) were inoculated on Days 0, 3, 6, and 9 (∼ 5 × 10⁷ cfu/mouse; n = 10–11/group), and killed on Day 13. All but one CF mouse survived to the termination of the study. *Significantly different differences in change in body weight from wild-type mice (p ⩽ 0.038; unpaired Student's t test, the Bonferroni method was used to adjust for multiple testing). (B) CF (open triangles) and wild-type mice (closed circles) were inoculated on Days 0 (5 × 10⁷ cfu/mouse), 2 (10⁸ cfu/mouse), and 4 (3 × 10⁷ cfu/mouse; n = 15/group), and killed on Day 8. Changes in sample size indicated in the figure are due to death. *Significant differences in change in body weight from wild type mice comparing groups where data are not censored by death (p = 0.009, unpaired Student t test; the Bonferroni method was used to adjust for multiple testing on Days 1 and 2).