TABLE 1.
PATIENT CHARACTERISTICS
| Single-Fiber Passive-Tension Studies
|
SDS–Agarose Studies
|
Microarray Studies
|
Immunofluorescence Microscopy
|
|||||
|---|---|---|---|---|---|---|---|---|
| Non-COPD (n = 5) | COPD (n = 7) | Non-COPD (n = 10) | COPD (n = 11) | Non-COPD (n = 6) | COPD (n = 5) | Non-COPD (n = 10) | COPD (n = 9) | |
| Male/female | 5/0 | 6/1 | 8/2 | 9/2 | 5/1 | 5/0 | 7/3 | 8/1 |
| Age, yr | 56 ± 4 | 60 ± 3 | 60 ± 3 | 60 ± 2 | 60 ± 4 | 61 ± 3 | 55 ± 3 | 59 ± 2 |
| BMI, kg/m2 | 27 ± 1 | 24 ± 2 | 27 ± 1 | 25 ± 2 | 28 ± 2 | 27 ± 3 | 27 ± 2 | 25 ± 2 |
| FEV1, % predicted | 102 ± 5 | 76 ± 8 | 92 ± 4 | 71 ± 7 | 93 ± 6 | 89 ± 9 | 93 ± 5 | 71 ± 5 |
| VC, % predicted | 97 ± 6 | 100 ± 12 | 84 ± 5 | 98 ± 9 | 86 ± 8 | 113 ± 13 | 91 ± 5 | 95 ± 7 |
| FEV1/VC, % | 82 ± 3 | 59 ± 2 | 77 ± 2 | 54 ± 3 | 78 ± 3 | 60 ± 2 | 78 ± 2 | 57 ± 2 |
| TLC, % predicted | 100 ± 11 | 99 ± 3 | 95 ± 4 | 106 ± 6 | 96 ± 6 | 116 ± 10 | 99 ± 3 | 102 ± 6 |
| DlCO/VA, % predicted | 89 ± 6 | 82 ± 7 | 96 ± 6 | 81 ± 5 | 97 ± 11 | 79 ± 11 | 97 ± 6 | 87 ± 4 |
| PaO2, kPa | 12.3 ± 0.0 | 11.5 ± 0.4 | 10.9 ± 0.5 | 11.4 ± 0.4 | 11.2 ± 0.7 | 11.4 ± 0.5 | 11.6 ± 0.4 | 11.7 ± 0.2 |
| PaCO2, kPa | 4.6 ± 0.0 | 4.8 ± 0.2 | 4.9 ± 0.1 | 5.2 ± 0.1 | 4.9 ± 0.1 | 4.7 ± 0.2 | 5.3 ± 0.2 | 5.3 ± 0.2 |
Definition of abbreviations: BMI = body mass index; COPD = chronic obstructive pulmonary disease; DlCO/VA = carbon monoxide transfer coefficient per alveolar volume; SDS = sodium dodecyl sulfate.
Patient characteristics for single fiber, SDS-agarose, microarray, and immunofluorescence microscopy studies.
Values are means ± SEM.