Figure 7.

Caspase inhibition improves survival and Kupffer cell ablation decreases survival after bacteremia. (A) Pretreatment with z-VAD-fmk followed by infection with severe bacteremia resulted in decreased mortality compared with severe bacteremia alone out to 48 h by log-rank test (p < 0.0424). Squares, z-VAD-fmk + severe bacteremia; inverted triangles, severe bacteremia. (B) Pretreatment with GdCl₃ followed by infection with mild bacteremia resulted in 100% mortality at 36 h. This is significantly increased compared with mild bacteremia alone by log-rank test (p < 0.0037). Squares, gadolinium + mild bacteremia; inverted triangles, mild bacteremia.