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. 2006 Apr 7;173(12):1377–1385. doi: 10.1164/rccm.200507-1014OC

Figure 6.

Figure 6.

Bombesin and GRP arrest alveolarization. GRPR-WT and GRPR-KO mice were treated with BN or left untreated, as described in Methods and in the legend to Figure 2. Lung tissue sections were stained with H&E to demonstrate alveolar architecture. Representative sections are given in (A)–(D): (A) GRPR-WT, untreated. (B) GRPR-KO, untreated. (C) GRPR-WT treated with BN. (D) GRPR-KO treated with BN. * Pleural surface. Scale bar in lower left hand corner = 50 μm. (E) Results of morphometry for mean linear intercept (MLI) in the above BN-treated groups (n = 8–10 animals per group; 10–12 20× fields per animal) (*p < 0.0001 compared with corresponding untreated group; †p < 0.001 compared with BN-treated WT pups). (F) Results of morphometry for MLI in similar groups, but treated with GRP rather than BN (n = 6–10 animals per group) (*p < 0.0001 compared with either the GRP-treated KO group or the corresponding PBS-treated WT group).