. 2005 Sep 22;173(1):64–70. doi: 10.1164/rccm.200503-505OC

TABLE 3.

ASTHMA ASSOCIATION AND QUANTITATIVE TRAIT ANALYSIS FOR T-BET SINGLE NUCLEOTIDE POLYMORPHISMS IN WHITE CAMP FAMILIES

		Asthma Association Analysis			Quantitative Trait Analysis^†
		FBAT p Value			FBAT-PC p Value
SNP	Allele	T:U^*	Additive Model	Dominant Model	logPC₂₀	FEV₁ (% pred)	logIgE
g.−19698	T	271:238	0.14	0.14	0.72	0.62	0.12
c.−7947	G	230:281	0.02	0.006	0.03	0.10	0.16
c.−1993	C	149:167	0.31	0.43	0.28	0.16	0.61
c.−1514	C	129:126	0.85	0.80	0.30	0.49	0.78
His33Gln	G	31:23	0.28	0.30	0.33	0.35	0.12
Gly130Gly	G	184:177	0.71	0.82	0.16	0.54	0.58
IVS1+238	T	116:118	0.90	0.51	0.39	0.31	0.70
IVS1+2354	A	126:127	0.95	0.75	0.22	0.17	0.95
IVS1+7240	C	107:86	0.13	0.09	0.29	0.34	0.04
IVS4-4	G	51:46	0.61	0.43	0.18	0.19	0.24
IVS5-22	T	138:139	0.95	0.92	0.24	0.79	0.74
Pro485Pro	A	21:20	0.88	1.00	0.07	0.27	0.44
c.2122	A	60:69	0.43	0.52	0.02^‡	0.08	0.12
c.2314	C	143:160	0.33	0.28	0.07	0.21	0.67
g.21126	T	60:71	0.34	0.52	0.02^‡	0.13	0.17
g.56983	C	53:60	0.51	0.62	0.04	0.09	0.25

Definition of abbreviations: CAMP = Childhood Asthma Management Program; SNP = single nucleotide polymorphism.

T:U denotes ratio of transmitted to untransmitted allele counts. T:U counts were derived using Haploview (17). p values are not corrected for multiple comparisons.

^†

An additive genetic model was assumed for quantitative trait analysis.

^‡

The c.2122- and g.21126-logPC₂₀ associations remained significant after rank-ordered Bonferroni correction based on power, as implemented in PBAT (p-adjusted 0.04 and 0.02, respectively) (21, 22).