TABLE 5.
BASELINE CHARACTERISTICS OF NORMATIVE AGING STUDY SUBJECTS GENOTYPED FOR T-BET SINGLE NUCLEOTIDE POLYMORPHISMS
| Median (interquartile range) or n (%)
|
||
|---|---|---|
| Variable* | Responders (n = 200) | Nonresponders (n = 436) |
| Age | 62 (5–68) | 59 (54–64) |
| History of asthma | 66 (33%) | 0 (0%) |
| FEV1, L | 2.68 (2.29–3.13) | 3.45 (3.11–3.79) |
| FEV1, % predicted | 90% (76–101%) | 108% (99.4–119%) |
| FEV1/FVC ratio | 0.734 (0.672–0.781) | 0.806 (0.770–0.841) |
| Methacholine dose–response slope | 3.26 (2.75–4.48) | 0.45 (0.36–0.53) |
| Total serum IgE | 51.5 (15.28–138.8) | 24.9 (8.8–64.5) |
| Eosinophil count | 229 (141–334) | 158 (88–246) |
| Skin-test positive > 2 mm† | 120 (60%) | 204 (46.8%) |
| Packs per day | 20 (0.1–45) | 7.5 (0–28) |
| Smoking status | ||
| Never | 50 (25%) | 157 (36%) |
| Past | 40 (20%) | 39 (8.9%) |
| Current | 110 (55%) | 240 (55%) |
*
Differences between responders and nonresponders significant at p < 0.01 for all variables.
†
Skin-test positivity to at least one of the following allergens: ragweed, house dust, mixed trees, mixed grass.