TABLE 2.
UPREGULATED GENES IN IDIOPATHIC PULMONARY FIBROSIS
| Gene Name | Locus-Link No. | TNoM p Value | t Test p Value |
|---|---|---|---|
| NM_017680: asporin (LRR class 1; ASPN), mRNA | 54829 | 4.0382E-05 | 0.00028842 |
| NM_033285: tumor protein p53 inducible nuclear protein 1 (TP53INP1), mRNA | 94241 | 0.00033652 | 2.5438E-06 |
| NM_000029: angiotensinogen (serine [or cysteine] proteinase; AGT), mRNA | 183 | 0.00033652 | 3.6249E-06 |
| NM_000861: histamine receptor H1 (HRH1), mRNA | 3269 | 0.00033652 | 1.6201E-05 |
| Hs.31386: secreted frizzled-related protein 2 | 6423 | 0.00033652 | 0.00020623 |
| NM_001792: cadherin 2, type 1, N-cadherin (neuronal) (CDH2), mRNA | 1000 | 0.00033652 | 0.00026976 |
| NM_005214: cytotoxic T-lymphocyte–associated protein 4 (CTLA4), mRNA | 1493 | 0.00033652 | 0.00039581 |
| NM_000577: interleukin-1 receptor antagonist (IL1RN), transcript variant 3, mRNA | 3557 | 0.00033652 | 0.00194308 |
| NM_033326: SRY (sex-determining region Y)-box 6 (SOX6), mRNA | 55553 | 0.00033652 | 0.0019824 |
| NM_004425: extracellular matrix protein 1 (ECM1), transcript variant 1, mRNA | 1893 | 0.00033652 | 0.00223442 |
| NM_001847: collagen, type IV, α6 (COL4A6), transcript variant A, mRNA | 1288 | 0.00033652 | 0.00342796 |
| NM_006475: osteoblast-specific factor 2 (fasciclin I-like; OSF-2), mRNA | 10631 | 0.00033652 | 0.00359433 |
| NM_130445: collagen, type XVIII, α1 (COL18A1), transcript variant 2, mRNA | 80781 | 0.00033652 | 0.00457581 |
| NM_002423: matrix metalloproteinase 7 (matrilysin, uterine; MMP7), mRNA | 4316 | 0.00033652 | 0.00486756 |
| NM_002991: chemokine (C-C motif) ligand 24 (CCL24), mRNA | 6369 | 0.00033652 | 0.0099309 |
| NM_000582: secreted phosphoprotein 1 (osteopontin, SPP1), mRNA | 6696 | 0.00201911 | 2.6178E-05 |
| Hs.156369: tenascin N | 63923 | 0.00201911 | 7.8339E-05 |
| NM_005268: gap junction protein, β5 (connexin 31.1; GJB5), mRNA | 2709 | 0.00201911 | 8.237E-05 |
| NM_000494: collagen, type XVII, α1 (COL17A1), transcript variant long, mRNA | 1308 | 0.00201911 | 8.792E-05 |
| NM_032888: collagen, type XXVII, α1 (COL27A1), mRNA | 85301 | 0.00201911 | 0.00012678 |
| Hs.9914: follistatin | 10468 | 0.00201911 | 0.0001307 |
| NM_022097: hepatocellular carcinoma antigen gene 520 (LOC63928), mRNA | 63928 | 0.00201911 | 0.00014831 |
| NM_001723: bullous pemphigoid antigen 1 (BPAG1), transcript variant 1e, mRNA | 667 | 0.00201911 | 0.00020654 |
| NM_006142: stratifin (SFN), mRNA | 2810 | 0.00201911 | 0.00030087 |
| NM_152999: six transmembrane epithelial antigen of prostate 2 (STEAP2), mRNA | 261729 | 0.00201911 | 0.00039041 |
| Hs.306692: epithelial membrane protein 1 | 2012 | 0.00201911 | 0.00042533 |
| NM_014799: hephaestin (HEPH), transcript variant 2, mRNA | 9843 | 0.00201911 | 0.00051385 |
| Hs.512555: collagen, type XIV, α1 (undulin) | 7373 | 0.00201911 | 0.00058874 |
| Hs.398100: mucin 6, gastric | 4588 | 0.00201911 | 0.00087085 |
| NM_003289: tropomyosin 2 (β; TPM2), mRNA | 7169 | 0.00201911 | 0.00090799 |
| NM_002546: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin; TNFRSF11B), mRNA | 4982 | 0.00201911 | 0.00106604 |
| NM_002785: pregnancy-specific β1-glycoprotein 11 (PSG11), mRNA | 5680 | 0.00201911 | 0.00148639 |
| NM_005786: serologically defined colon cancer antigen 33 (SDCCAG33), mRNA | 10194 | 0.00201911 | 0.00134524 |
| NM_002421: matrix metalloproteinase 1 (interstitial collagenase; MMP1), mRNA | 4312 | 0.00201911 | 0.00180712 |
| NM_014476: α-actinin-2–associated LIM protein (ALP), mRNA | 27295 | 0.00201911 | 0.00185632 |
| NM_153756: fibronectin type III domain containing 5 (FNDC5), mRNA | 252995 | 0.00201911 | 0.00225902 |
| NM_004385: chondroitin sulfate proteoglycan 2 (versican; CSPG2), mRNA | 1462 | 0.00201911 | 0.00284683 |
| NM_001552: insulinlike growth factor binding protein 4 (IGFBP4), mRNA | 3487 | 0.00201911 | 0.003664 |
| Hs.443625: collagen, type III, α1 | 1281 | 0.00201911 | 0.00486324 |
| NM_000599: insulinlike growth factor binding protein 5 (IGFBP5), mRNA | 3488 | 0.00201911 | 0.00619535 |
| NM_001855: collagen, type XV, α1 (COL15A1), mRNA | 1306 | 0.00201911 | 0.00778896 |
| NM_004363: carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), mRNA | 1048 | 0.00201911 | 0.00834501 |
| Hs.169849: myosin binding protein C, slow type | 4604 | 0.00928793 | 0.00042598 |
| NM_003882: WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 1, mRNA | 8840 | 0.00928793 | 0.0004304 |
| Hs.172028: a disintegrin and metalloproteinase domain 10 | 102 | 0.00928793 | 0.00046155 |
| Hs.58324: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | 11096 | 0.00928793 | 0.00105437 |
| Hs.56255: keratin 6 irs4 | 121391 | 0.00928793 | 0.00155258 |
| Hs.443567: transitional epithelia response protein | 29914 | 0.00928793 | 0.00190983 |
| NM_001793: cadherin 3, type 1, P-cadherin (placental; CDH3), mRNA | 1001 | 0.00928793 | 0.00217983 |
| Hs.352156: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 | 140766 | 0.00928793 | 0.00277865 |
| NM_015444: Ras-induced senescence 1 (RIS1), mRNA | 25907 | 0.00928793 | 0.00397939 |
| Hs.28005: transforming growth factor, β receptor I (activin A receptor type II–like kinase, 53 kD) | 7046 | 0.00928793 | 0.00403024 |
| NM_002273: keratin 8 (KRT8), mRNA | 3856 | 0.00928793 | 0.00463512 |
| NM_007159: sarcolemma-associated protein (SLMAP), mRNA | 7871 | 0.00928793 | 0.00467059 |
| NM_053025: myosin, light polypeptide kinase (MYLK), transcript variant 1, mRNA | 4638 | 0.00928793 | 0.00584138 |
| NM_000640: interleukin-13 receptor, α2 (IL13RA2), mRNA | 3598 | 0.00928793 | 0.00666183 |
| NM_012134: leiomodin 1 (smooth muscle; LMOD1), mRNA | 25802 | 0.00928793 | 0.00847851 |
| NM_000094: collagen, type VII, α1 (COL7A1), mRNA | 1294 | 0.00928793 | 0.00937536 |
| NM_001202: bone morphogenetic protein 4 (BMP4), transcript variant 1, mRNA | 652 | 0.00928793 | 0.00953431 |
Definition of abbreviation: TNoM = threshold number of misclassifications.