TABLE 3.
UPREGULATED GENES IN HYPERSENSITIVITY PNEUMONITIS
| Gene Name | Locus-Link No. | TNoM p Value | t Test p Value |
|---|---|---|---|
| NM_005516: major histocompatibility complex, class I, E (HLA-E), mRNA | 3133 | 3.1063E-06 | 8.581E-08 |
| NM_002985: chemokine (C-C motif) ligand 5 (CCL5), mRNA | 6352 | 3.1063E-06 | 1.1854E-07 |
| Hs.351874: major histocompatibility complex, class II, DOα | 3111 | 3.1063E-06 | 2.0498E-07 |
| Hs.368409: major histocompatibility complex, class II, DP β1 | 3115 | 3.1063E-06 | 2.6687E-06 |
| NM_014387: linker for activation of T cells (LAT), mRNA | 27040 | 3.1063E-06 | 2.9103E-06 |
| NM_000732: CD3D antigen, δ polypeptide (TiT3 complex; CD3D), mRNA | 915 | 4.0382E-05 | 1.1558E-06 |
| NM_002209: integrin, αL (antigen CD11A [p180], lymphocyte function–associated antigen 1; α polypeptide; ITGAL), mRNA | 3683 | 4.0382E-05 | 1.3539E-06 |
| NM_002198: interferon regulatory factor 1 (IRF1), mRNA | 3659 | 4.0382E-05 | 2.2803E-06 |
| NM_005601: natural killer cell group 7 sequence (NKG7), mRNA | 4818 | 4.0382E-05 | 2.5394E-06 |
| NM_001767: CD2 antigen (p50), sheep red blood cell receptor (CD2), mRNA | 914 | 4.0382E-05 | 3.4159E-06 |
| NM_001558: interleukin-10 receptor, α (IL10RA), mRNA | 3587 | 4.0382E-05 | 1.0847E-05 |
| NM_006120: major histocompatibility complex, class II, DMα (HLA-DMA), mRNA | 3108 | 4.0382E-05 | 1.141E-05 |
| NM_002118: major histocompatibility complex, class II, DMβ (HLA-DMB), mRNA | 3109 | 4.0382E-05 | 1.3627E-05 |
| NM_000246: MHC class II transactivator (MHC2TA), mRNA | 4261 | 4.0382E-05 | 2.1963E-05 |
| NM_001109: a disintegrin and metalloproteinase domain 8 (ADAM8), mRNA | 101 | 4.0382E-05 | 3.0077E-05 |
| NM_000565: interleukin-6 receptor (IL6R), transcript variant 1, mRNA | 3570 | 4.0382E-05 | 3.5004E-05 |
| NM_004355: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated; CD74) | 972 | 4.0382E-05 | 4.5692E-05 |
| NM_000206: interleukin-2 receptor, γ (severe combined immunodeficiency; IL2RG), mRNA | 3561 | 4.0382E-05 | 5.3729E-05 |
| NM_001778: CD48 antigen (B-cell membrane protein; CD48), mRNA | 962 | 4.0382E-05 | 0.00019398 |
| NM_002339: lymphocyte-specific protein 1 (LSP1), mRNA | 4046 | 4.0382E-05 | 0.0004061 |
| NM_006144: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3; GZMA), mRNA | 3001 | 0.00033652 | 3.5408E-06 |
| NM_003874: CD84 antigen (leukocyte antigen; CD84), mRNA | 8832 | 0.00033652 | 2.1163E-05 |
| Hs.181244: major histocompatibility complex, class I, A | 3105 | 0.00033652 | 2.3716E-05 |
| NM_000265: neutrophil cytosolic factor 1 (47 kD, chronic granulomatous disease, autosomal 1; NCF1), mRNA | 4687 | 0.00033652 | 2.7125E-05 |
| NM_001768: CD8 antigen, α polypeptide (p32) (CD8A), transcript variant 1, mRNA | 925 | 0.00033652 | 3.6982E-05 |
| NM_004355: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated; CD74) | 972 | 0.00033652 | 3.7304E-05 |
| Hs.387679: major histocompatibility complex, class II, DQ α1 | 3117 | 0.00033652 | 7.4311E-05 |
| Hs.387787: killer cell lectinlike receptor subfamily K, member 1 | 22914 | 0.00033652 | 0.00010199 |
| NM_003019: surfactant, pulmonary-associated protein D (SFTPD), mRNA | 6441 | 0.00033652 | 0.00015899 |
| NM_016326: chemokine-like factor (CKLF), transcript variant 3, mRNA | 51192 | 0.00033652 | 0.00027442 |
| NM_001242: tumor necrosis factor receptor superfamily, member 7 (TNFRSF7), mRNA | 939 | 0.00033652 | 0.00038993 |
| NM_012292: minor histocompatibility antigen HA-1 (HA-1), mRNA | 23526 | 0.00033652 | 0.00046328 |
| NM_000878: interleukin-2 receptor, β (IL2RB), mRNA | 3560 | 0.00033652 | 0.00531621 |
| NM_003879: CASP8 and FADD-like apoptosis regulator (CFLAR), mRNA | 8837 | 0.00033652 | 0.00648208 |
| NM_002984: chemokine (C-C motif) ligand 4 (CCL4), mRNA | 6351 | 0.00201911 | 6.3196E-06 |
| NM_002416: chemokine (C-X-C motif) ligand 9 (CXCL9), mRNA | 4283 | 0.00201911 | 5.4339E-05 |
| NM_004221: natural killer cell transcript 4 (NK4), mRNA | 9235 | 0.00201911 | 9.8112E-05 |
| NM_021181: SLAM family member 7 (SLAMF7), mRNA | 57823 | 0.00201911 | 0.00016428 |
| NM_000063: complement component 2 (C2), mRNA | 717 | 0.00201911 | 0.00024703 |
| NM_172369: complement component 1, q subcomponent, gamma polypeptide (C1QG), RNA | 714 | 0.00201911 | 0.00040263 |
| NM_003467: chemokine (C-X-C motif) receptor 4 (CXCR4), mRNA | 7852 | 0.00201911 | 0.00043211 |
| NM_001079: ζ-chain (TCR)–associated protein kinase 70 kD (ZAP70), mRNA | 7535 | 0.00201911 | 0.00061774 |
| NM_020125: SLAM family member 8 (SLAMF8), mRNA | 56833 | 0.00201911 | 0.00062281 |
| NM_001565: chemokine (C-X-C motif) ligand 10 (CXCL10), mRNA | 3627 | 0.00201911 | 0.00109636 |
| NM_004513: interleukin 16 (lymphocyte chemoattractant factor; IL16), transcript variant 1, RNA | 3603 | 0.00201911 | 0.00188205 |
| NM_005781: activated Cdc42-associated kinase 1 (ACK1), mRNA | 10188 | 0.00201911 | 0.00213368 |
| NM_007261: leukocyte membrane antigen (CMRF-35H), mRNA | 11314 | 0.00201911 | 0.00214496 |
| NM_153461: interleukin-17 receptor C (IL17RC), transcript variant 1, mRNA | 84818 | 0.00201911 | 0.0026955 |
| NM_000733: CD3E antigen, ɛ polypeptide (TiT3 complex; CD3E), mRNA | 916 | 0.00201911 | 0.00294939 |
| NM_021798: interleukin-21 receptor (IL21R), transcript variant 1, mRNA | 50615 | 0.00201911 | 0.003582 |
| NM_001953: endothelial cell growth factor 1 (platelet-derived; ECGF1), mRNA | 1890 | 0.00201911 | 0.00438273 |
| NM_000579: chemokine (C-C motif) receptor 5 (CCR5), mRNA | 1234 | 0.00928793 | 9.6163E-05 |
| NM_019111: major histocompatibility complex, class II, DR α (HLA-DRA), mRNA | 3122 | 0.00928793 | 0.00036044 |
| NM_003820: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator; TNFRSF14), mRNA | 8764 | 0.00928793 | 0.00041457 |
| Hs.409934: major histocompatibility complex, class II, DQ β1 | 3119 | 0.00928793 | 0.00055793 |
| NM_006926: surfactant, pulmonary-associated protein A2 (SFTPA2), mRNA | 6436 | 0.00928793 | 0.0007712 |
| NM_015259: inducible T-cell costimulator ligand (ICOSL), mRNA | 23308 | 0.00928793 | 0.00281981 |
| NM_001774: CD37 antigen (CD37), mRNA | 951 | 0.00928793 | 0.00288764 |
| NM_001784: CD97 antigen (CD97), transcript variant 2, mRNA | 976 | 0.00928793 | 0.00541578 |
| NM_014312: cortical thymocyte receptor (X. laevis CTX) like (CTXL), mRNA | 23584 | 0.00928793 | 0.00621325 |
| NM_003810: tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), mRNA | 8743 | 0.00928793 | 0.00811714 |
For definition of abbreviation, see Table 2.