TABLE 3.
Population PK parameter estimates for HCQ after administration of a single oral dose of HCQ sulfate (400 mg) in the PK studies (studies Ia, Ib, and II)a
| Parameter | ka (h−1) | ALAG (h) | IIV of ALAG | Vc (liters) | IIV of Vc | Vp (liters) | IIV of Vp | Q (liters/h) | CL/F (liters/h) | IIV of CL/F | ɛ1 (proportional) | ɛ2 (additive) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimated value | 1.15 | 0.389 | 0.0359 | 437 | 0.232 | 1,390 | 0.715 | 45.1 | 10.9 | 0.161 | 0.27b | 2.77b |
| % RSE | 15.7 | 8.8 | 61.1 | 17.8 | 57.8 | 17.8 | 22.3 | 16.6 | 21.5 | 41 | 7.3 | 37.5 |
| 95% CI | 0.80-1.50 | 0.32-0.46 | −0.09 | 284-589 | −0.53 | 905-1,875 | 0.40-1.03 | 30.4-59.8 | 6.3-15.5 | 0.03-0.29 | 0.49-0.57 | 0.84-4.81 |
| Bootstrap estimate | 1.09 | 0.39 | 0.15 | 443 | 0.47 | 1,484 | 0.57 | 47.1 | 11.1 | 0.3 | 0.27 | 2.16 |
| Bootstrap 95% CI | 0.61-1.53 | 0.32-0.49 | 0.00-0.35 | 230-615 | 0.12-0.76 | 919-2,141 | 0.44-0.71 | 30.6-61.3 | 7.9-14.6 | 0.19-0.37 | 0.23-0.29 | 1.43-3.63 |
a
Abbreviations: RSE, relative standard error (standard error divided by the parameter estimate); CI, confidence interval; IIV, interindividual variability; ka, absorption rate constant; ALAG, absorption lag time; Vc, central volume of distribution; Vp, peripheral volume of distribution; Q, intercompartmental clearance.
b
The values represent standard deviations.