TABLE 1.

Bacterial tissue burdens and ratios of A_0.5 CFU to strain B_2.0 CFU in untreated control rabbits and in rabbits treated with daptomycin for 4 days in a dual-infection aortic valve endocarditis model

Groupa	Endocardial vegetations		Spleens		Kidneys
	Log10 CFU/gb	A0.5/B2.0 CFU ratioc	Log10 CFU/g	A0.5/B2.0 CFU ratio	Log10 CFU/g	A0.5/B2.0 CFU ratio
No DAP (n = 6)	7.8 ± 0.4	280:320	6.0 ± 0.3	333:267	6.3 ± 1.0	360:240
DAP-12 (n = 7)d	5.3 ± 2.1e	1:604	2.3 ± 1.3f	1:175	1.7 ± 2.2f	0:156

^aThe two groups were untreated control rabbits (no daptomycin [No DAP]) and rabbits treated with 12 mg of daptomycin/kg/day for 4 days (DAP-12).

^bBacterial tissue burdens are shown as log₁₀ CFU/g (means ± standard deviations).

^cThe A_0.5/B_2.0 ratio is the total number of CFU for each tissue for all rabbits tested in the group that grew on blood agar minus the total number of CFU that grew on rifampin-containing agar (i.e., strain A_0.5 CFU) to the total number of CFU that grew on rifampin-containing agar only (i.e., strain B_2.0 CFU) (P < 0.0001 for the ratio for the no-DAP group versus the DAP-12 group by the Fisher exact test).

^dThere were no deaths occurring in this group on therapy.

^eSignificantly different from the value obtained for the no-DAP group (P < 0.05 by unpaired t test).

^fSignificantly different from the value obtained for the no-DAP group (P < 0.001 by unpaired t test).