TABLE 2.

Bacterial tissue burdens in rabbits infected with strain A_0.5 and untreated or treated with two different doses of daptomycin in an aortic valve endocarditis model^a

Groupb	Bacterial tissue burden (log10 CFU/g) (mean ± SD) in:
	Endocardial vegetations	Spleens	Kidneys
No DAP (n = 5)	6.9 ± 0.7	6.1 ± 0.2	5.7 ± 0.7
DAP-12 (n = 4)c	0 ± 0e	0 ± 0e	0 ± 0e
DAP-18 (n = 5)d	0 ± 0e	0 ± 0e	0 ± 0e

^aA daptomycin dose of 12 mg/kg in rabbits produced an AUC of 719 μg · h/ml, comparable to the human 6-mg/kg dose (which produced an AUC of 632 μg · h/ml). A daptomycin dose of 18 mg/kg in rabbits produced an AUC of 965 μg · h/ml, comparable to the human 10-mg/kg dose (which produced an AUC of 1,039 μg · h/ml).

^bThe three groups were untreated control rabbits (no daptomycin [No DAP]) and rabbits treated with 12 mg of daptomycin/kg/day for 4 days (DAP-12) or 18 mg of daptomycin/kg/day for 4 days (DAP-18).

^cSix rabbits were allocated to this arm. One rabbit was found dead on day 2 after receiving only one dose of daptomycin, and one rabbit was found moribund and euthanized on day 2 after receiving only one dose of daptomycin; neither of these rabbits was included in the data analysis.

^dFive rabbits were allocated to this arm. Two rabbits died on day 2 having received two doses of daptomycin, and both were included in the data analysis.

^eSignificantly different from the value obtained for the no-DAP group (P < 0.001). All cultures from the daptomycin-treated animals were sterile.