TABLE 3.

Covariance matrix in lower triangular form

Parameter	Covariance
	Ki	KS	K12	K21	V1
Ki	0.0037
KS	−0.0001	0.0001
K12	−0.0370	0.0008	1.0466
K21	−0.0136	−0.0015	0.7208	1.1717
V1	0.0026	−0.0011	−0.0455	0.0346	0.0348

K_i, the y intercept of the elimination rate constant; K_S, the slope of the elimination rate constant; K₁₂, intercompartmental transfer rate constant from the central to the peripheral compartment; K₂₁, intercompartmental transfer rate constant from the peripheral to the central compartment; V₁, volume of distribution of the central compartment.