TABLE 1.
Patient no. or location | Strain | MIC [mg/liter] at baseline (test of cure)
|
Type of UTI | Therapy | Microbiological/ clinical success | Genotypic relationship | |
---|---|---|---|---|---|---|---|
Doripenem | Levofloxacin | ||||||
NAb | P. aeruginosa ATCC 27853 | 0.12-0.5 | 0.25 | NA | NA | NA | NA |
U.S.b | E. coli 1135121 | ≤0.015 (≤0.015) | 4 (4) | Lower cUTI | Levofloxacin | MFe | Closely related |
U.S.b | P. mirabilis 1134841 | 0.03 (0.03) | >8 (64) | Lower cUTI | Doripenem | MFe | Identical |
U.S.b | P. aeruginosa 1134642 | 2 (0.25) | 16 (>8) | Lower cUTI | Doripenem | MFe | Closely related |
U.S.b | S. aureus 1134684 | 32 (32) | 4 (4) | Lower cUTI | Levofloxacin | MFe | Closely related |
07145b,c | E. coli 1949820 B-N | 0.03 (0.03) | 8 (8) | s lower cUTI | Levofloxacin | MF, CF | Indistinguishable |
08004b,c | E. faecalis 1780065 B-B | 4 (4) | 1 (1) | as lower cUTI | Levofloxacin | MF | Indistinguishable |
07141b,c,d | E. coli 1949821 B-M | ≤0.015 | 0.125 | s lower cUTI | Doripenem | Yes | NA |
07141c,d | S. haemolyticus 1949819 B-M | 1 | NA | s lower cUTI | Doripenem | Yes | NA |
08014c,d | E. faecalis 2297262-10 B-V | NA | >32 | as lower cUTI | Levofloxacin | Yes | NA |
08014c,d | S. epidermidis 2297262-9 B-V | NA | >32 | as lower cUTI | Levofloxacin | Yes | NA |
18010c,d | E. faecalis 2215767-10 B-S | NA | >32 | as lower cUTI | Levofloxacin | MF | ND |
18010c,d | S. aureus 2215767-9 B-S | NA | >32 | as lower cUTI | Levofloxacin | MF | ND |
08015c | E. coli 2297257 B-W | 0.015 | NA | as lower cUTI | Doripenem | Yes | NA |
09031c | E. coli 1780064 A-X | NA | 0.047 | Pyelonephritis | Levofloxacin | Yes | NA |
07071c | E. coli 1655646 A-Y | NA | 0.047 | s lower cUTI | Levofloxacin | Yes | NA |
09034c | E. coli 1780063 B-A | 0.03 | NA | Pyelonephritis | Doripenem | Yes | NA |
07090c | E. coli 1821385 B-C | 0.03 | NA | s lower cUTI | Doripenem | Yes | NA |
17081c | E. coli 1821386 B-D | NA | <0.03 | s lower cUTI | Levofloxacin | Yes | NA |
08007c | E. coli 1889646 B-F | 0.03 (0.03) | >8 (8) | as lower cUTI | Doripenem | MF | Unrelated |
07121c | E. coli 1889647 B-H | NA | <0.03 | s lower cUTI | Levofloxacin | Yes | NA |
07124c | E. coli 1889645 B-I | 0.03 | NA | s lower cUTI | Doripenem | Yes | NA |
07134c | E. coli 1949825 B-K | 0.03 (0.03) | 0.03 (0.03) | s lower cUTI | Doripenem | MF | Closely related |
09053c | E. coli 1949826 B-L | 0.03 | NA | Pyelonephritis | Doripenem | Yes | NA |
07164c | E. coli 2062717 B-P | ≤0.015 (≤0.015) | 8 (4) | s lower cUTI | Doripenem | MF | Closely related |
07180c | E. coli 2062716 B-R | NA | 0.032 | s lower cUTI | Levofloxacin | Yes | NA |
08013c | S. marcescens 2297260 B-U | NA | 0.19 | as lower cUTI | Levofloxacin | Yes | NA |
08005c | P. aeruginosa 1821383 B-E | NA | 0.25 | as lower cUTI | Levofloxacin | Yes | NA |
07168c | P. aeruginosa 2062713 B-Q | 0.5 (0.5) | 0.06 (0.25) | s lower cUTI | Levofloxacin | MF | Indistinguishable |
07199c | E. faecalis 2215770 B-T | 0.25 | NA | s lower cUTI | Doripenem | Yes | NA |
08003c | S. aureus 1889640 A-Z | NA | 0.06 | as lower cUTI | Levofloxacin | Yes | NA |
08008c | S. epidermidis 1949822 B-J | >32 (>32) | 8 (8) | as lower cUTI | Levofloxacin | MF | Unrelated |
NA, not applicable; ND, not done; s, symptomatic; as, asymptomatic; MF, microbiological failure; CF, clinical failure.
Strain was tested for all patients.
Strain was tested in urine sample from individual patient from whom the strain was isolated.
Two strains isolated per patient.
Patients were not part of this study; only strains isolated from these patients were used.