TABLE 1.
Strains and MICs of doripenem and levofloxacin used in this studya
| Patient no. or location | Strain | MIC [mg/liter] at baseline (test of cure)
|
Type of UTI | Therapy | Microbiological/ clinical success | Genotypic relationship | |
|---|---|---|---|---|---|---|---|
| Doripenem | Levofloxacin | ||||||
| NAb | P. aeruginosa ATCC 27853 | 0.12-0.5 | 0.25 | NA | NA | NA | NA |
| U.S.b | E. coli 1135121 | ≤0.015 (≤0.015) | 4 (4) | Lower cUTI | Levofloxacin | MFe | Closely related |
| U.S.b | P. mirabilis 1134841 | 0.03 (0.03) | >8 (64) | Lower cUTI | Doripenem | MFe | Identical |
| U.S.b | P. aeruginosa 1134642 | 2 (0.25) | 16 (>8) | Lower cUTI | Doripenem | MFe | Closely related |
| U.S.b | S. aureus 1134684 | 32 (32) | 4 (4) | Lower cUTI | Levofloxacin | MFe | Closely related |
| 07145b,c | E. coli 1949820 B-N | 0.03 (0.03) | 8 (8) | s lower cUTI | Levofloxacin | MF, CF | Indistinguishable |
| 08004b,c | E. faecalis 1780065 B-B | 4 (4) | 1 (1) | as lower cUTI | Levofloxacin | MF | Indistinguishable |
| 07141b,c,d | E. coli 1949821 B-M | ≤0.015 | 0.125 | s lower cUTI | Doripenem | Yes | NA |
| 07141c,d | S. haemolyticus 1949819 B-M | 1 | NA | s lower cUTI | Doripenem | Yes | NA |
| 08014c,d | E. faecalis 2297262-10 B-V | NA | >32 | as lower cUTI | Levofloxacin | Yes | NA |
| 08014c,d | S. epidermidis 2297262-9 B-V | NA | >32 | as lower cUTI | Levofloxacin | Yes | NA |
| 18010c,d | E. faecalis 2215767-10 B-S | NA | >32 | as lower cUTI | Levofloxacin | MF | ND |
| 18010c,d | S. aureus 2215767-9 B-S | NA | >32 | as lower cUTI | Levofloxacin | MF | ND |
| 08015c | E. coli 2297257 B-W | 0.015 | NA | as lower cUTI | Doripenem | Yes | NA |
| 09031c | E. coli 1780064 A-X | NA | 0.047 | Pyelonephritis | Levofloxacin | Yes | NA |
| 07071c | E. coli 1655646 A-Y | NA | 0.047 | s lower cUTI | Levofloxacin | Yes | NA |
| 09034c | E. coli 1780063 B-A | 0.03 | NA | Pyelonephritis | Doripenem | Yes | NA |
| 07090c | E. coli 1821385 B-C | 0.03 | NA | s lower cUTI | Doripenem | Yes | NA |
| 17081c | E. coli 1821386 B-D | NA | <0.03 | s lower cUTI | Levofloxacin | Yes | NA |
| 08007c | E. coli 1889646 B-F | 0.03 (0.03) | >8 (8) | as lower cUTI | Doripenem | MF | Unrelated |
| 07121c | E. coli 1889647 B-H | NA | <0.03 | s lower cUTI | Levofloxacin | Yes | NA |
| 07124c | E. coli 1889645 B-I | 0.03 | NA | s lower cUTI | Doripenem | Yes | NA |
| 07134c | E. coli 1949825 B-K | 0.03 (0.03) | 0.03 (0.03) | s lower cUTI | Doripenem | MF | Closely related |
| 09053c | E. coli 1949826 B-L | 0.03 | NA | Pyelonephritis | Doripenem | Yes | NA |
| 07164c | E. coli 2062717 B-P | ≤0.015 (≤0.015) | 8 (4) | s lower cUTI | Doripenem | MF | Closely related |
| 07180c | E. coli 2062716 B-R | NA | 0.032 | s lower cUTI | Levofloxacin | Yes | NA |
| 08013c | S. marcescens 2297260 B-U | NA | 0.19 | as lower cUTI | Levofloxacin | Yes | NA |
| 08005c | P. aeruginosa 1821383 B-E | NA | 0.25 | as lower cUTI | Levofloxacin | Yes | NA |
| 07168c | P. aeruginosa 2062713 B-Q | 0.5 (0.5) | 0.06 (0.25) | s lower cUTI | Levofloxacin | MF | Indistinguishable |
| 07199c | E. faecalis 2215770 B-T | 0.25 | NA | s lower cUTI | Doripenem | Yes | NA |
| 08003c | S. aureus 1889640 A-Z | NA | 0.06 | as lower cUTI | Levofloxacin | Yes | NA |
| 08008c | S. epidermidis 1949822 B-J | >32 (>32) | 8 (8) | as lower cUTI | Levofloxacin | MF | Unrelated |
a
NA, not applicable; ND, not done; s, symptomatic; as, asymptomatic; MF, microbiological failure; CF, clinical failure.
b
Strain was tested for all patients.
c
Strain was tested in urine sample from individual patient from whom the strain was isolated.
d
Two strains isolated per patient.
e
Patients were not part of this study; only strains isolated from these patients were used.