TABLE 3.

Reciprocal UBTs and AUBTs of doripenem or levofloxacin for 27 individual patients' strains^a

Drug or strain	MIC (mg/liter)	UBT for indicated collection period (h)						AUBT, 24 h	Type of UTI	Eradication	Genotype
		0-4	4-8	8-12	12-16	16-20	20-24
Doripenem
E. coli 1949821 B-Mb	≤0.015	16,384	4,096	32,768	4,096	32,768	4,096	376,832	s lower cUTI	Yes	NA
S. haemolyticus 1949819 B-Mb	1	512	128	1,024	128	2,048	128	15,872	s lower cUTI	Yes	NA
E. coli 2297257 B-W	0.03	4,096	2,048	16,384	4,096	32,768	4,096	253,952	as lower cUTI	Yes	NA
E. coli 1780063 B-A	0.03	4,096	1,024	4,096	1,024	4,096	1,024	61,440	Pyelonephritis	Yes	NA
E. coli 1821385 B-C	0.03	4,096	256	32,768	8,192	8,192	256	215,040	s lower cUTI	Yes	NA
E. coli 1889646 B-F	0.03	65,536	32,768	32,768	8,192	65,536	65,536	1,081,344	as lower cUTI	MF	Unrelated
E. coli 1889645 B-I	0.03	65,536	32,768	131,072	32,768	65,536	4,096	1,327,104	s lower cUTI	Yes	NA
E. coli 1949825 B-K	0.03	16,384	4,096	8,192	2,048	4,096	256	140,288	s lower cUTI	MF	Closely related
E. coli 1949826 B-L	0.03	65,536	32,768	131,072	32,768	65,536	16,384	1,376,256	Pyelonephritis	Yes	NA
E. coli 2062717 B-P	≤0.015	32,768	1,024	1,024	512	32,768	2,048	280,576	s lower cUTI	MF	Closely related
E. faecalis 2215770 B-T	0.25	2,048	512	1,024	512	2,048	512	25,600	s lower cUTI	Yes	NA
Levofloxacin
E. faecalis 2297262-10 B-Vb	>32	0	0	0	0	0	0	0	as lower cUTI	Yes	NA
S. epidermidis 2297262-9 B-Vb	>32	1	1	4	2	2	2	48	as lower cUTI	Yes	NA
E. faecalis 1780065 B-B	1	16	8	4	4	4	2	152	as lower cUTI	MF	Indistinguishable
E. faecalis 2215767-10 B-Sb	>32	0	0	1	0	0	0	4	as lower cUTI	MF	ND
S. aureus 2215767-9 B-Sb	>32	0	0	1	0	0	0	4	as lower cUTI	MF	ND
E. coli 1780064 A-X	0.047	1,024	512	256	128	256	128	9,216	Pyelonephritis	Yes	NA
E. coli 1655646 A-Y	0.047	2,048	2,048	2,048	1,024	1,024	256	33,792	s lower cUTI	Yes	NA
E. coli 1821386 B-D	<0.03	2,048	8,192	2,048	4,096	2,048	2,048	81,920	s lower cUTI	Yes	NA
E. coli 1949820 B-N	8	0	0	0	0	0	0	0	s lower cUTI	MF, CF	Indistinguishable
E. coli 1889647 B-H	<0.03	2,048	2,048	512	1,024	512	256	25,600	s lower cUTI	Yes	NA
E. coli 2062716 B-R	0.032	1,024	512	512	256	128	64	9,984	s lower cUTI	Yes	NA
S. marcescens 2297260 B-U	0.19	512	256	128	128	32	32	4,352	as lower cUTI	Yes	NA
P. aeruginosa 1821383 B-E	0.25	32	128	128	128	128	16	2,240	as lower cUTI	Yes	NA
P. aeruginosa 2062713 B-Q	0.38	8	4	4	4	4	2	104	s lower cUTI	MF	Indistinguishable
S. aureus 1889640 A-Z	0.06	256	128	128	128	64	64	3,072	as lower cUTI	Yes	NA
S. epidermidis 1949822 B-J	8	4	4	2	4	2	1	64	as lower cUTI	MF	Unrelated

^aEleven patients were treated with doripenem and 16 with levofloxacin. MF, microbiological failure; CF, clinical failure; s, symptomatic; as, asymptomatic.

^bTwo strains isolated per patient.