TABLE 3.
Drug or strain | MIC (mg/liter) | UBT for indicated collection period (h)
|
AUBT, 24 h | Type of UTI | Eradication | Genotype | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
0-4 | 4-8 | 8-12 | 12-16 | 16-20 | 20-24 | ||||||
Doripenem | |||||||||||
E. coli 1949821 B-Mb | ≤0.015 | 16,384 | 4,096 | 32,768 | 4,096 | 32,768 | 4,096 | 376,832 | s lower cUTI | Yes | NA |
S. haemolyticus 1949819 B-Mb | 1 | 512 | 128 | 1,024 | 128 | 2,048 | 128 | 15,872 | s lower cUTI | Yes | NA |
E. coli 2297257 B-W | 0.03 | 4,096 | 2,048 | 16,384 | 4,096 | 32,768 | 4,096 | 253,952 | as lower cUTI | Yes | NA |
E. coli 1780063 B-A | 0.03 | 4,096 | 1,024 | 4,096 | 1,024 | 4,096 | 1,024 | 61,440 | Pyelonephritis | Yes | NA |
E. coli 1821385 B-C | 0.03 | 4,096 | 256 | 32,768 | 8,192 | 8,192 | 256 | 215,040 | s lower cUTI | Yes | NA |
E. coli 1889646 B-F | 0.03 | 65,536 | 32,768 | 32,768 | 8,192 | 65,536 | 65,536 | 1,081,344 | as lower cUTI | MF | Unrelated |
E. coli 1889645 B-I | 0.03 | 65,536 | 32,768 | 131,072 | 32,768 | 65,536 | 4,096 | 1,327,104 | s lower cUTI | Yes | NA |
E. coli 1949825 B-K | 0.03 | 16,384 | 4,096 | 8,192 | 2,048 | 4,096 | 256 | 140,288 | s lower cUTI | MF | Closely related |
E. coli 1949826 B-L | 0.03 | 65,536 | 32,768 | 131,072 | 32,768 | 65,536 | 16,384 | 1,376,256 | Pyelonephritis | Yes | NA |
E. coli 2062717 B-P | ≤0.015 | 32,768 | 1,024 | 1,024 | 512 | 32,768 | 2,048 | 280,576 | s lower cUTI | MF | Closely related |
E. faecalis 2215770 B-T | 0.25 | 2,048 | 512 | 1,024 | 512 | 2,048 | 512 | 25,600 | s lower cUTI | Yes | NA |
Levofloxacin | |||||||||||
E. faecalis 2297262-10 B-Vb | >32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | as lower cUTI | Yes | NA |
S. epidermidis 2297262-9 B-Vb | >32 | 1 | 1 | 4 | 2 | 2 | 2 | 48 | as lower cUTI | Yes | NA |
E. faecalis 1780065 B-B | 1 | 16 | 8 | 4 | 4 | 4 | 2 | 152 | as lower cUTI | MF | Indistinguishable |
E. faecalis 2215767-10 B-Sb | >32 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | as lower cUTI | MF | ND |
S. aureus 2215767-9 B-Sb | >32 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | as lower cUTI | MF | ND |
E. coli 1780064 A-X | 0.047 | 1,024 | 512 | 256 | 128 | 256 | 128 | 9,216 | Pyelonephritis | Yes | NA |
E. coli 1655646 A-Y | 0.047 | 2,048 | 2,048 | 2,048 | 1,024 | 1,024 | 256 | 33,792 | s lower cUTI | Yes | NA |
E. coli 1821386 B-D | <0.03 | 2,048 | 8,192 | 2,048 | 4,096 | 2,048 | 2,048 | 81,920 | s lower cUTI | Yes | NA |
E. coli 1949820 B-N | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | s lower cUTI | MF, CF | Indistinguishable |
E. coli 1889647 B-H | <0.03 | 2,048 | 2,048 | 512 | 1,024 | 512 | 256 | 25,600 | s lower cUTI | Yes | NA |
E. coli 2062716 B-R | 0.032 | 1,024 | 512 | 512 | 256 | 128 | 64 | 9,984 | s lower cUTI | Yes | NA |
S. marcescens 2297260 B-U | 0.19 | 512 | 256 | 128 | 128 | 32 | 32 | 4,352 | as lower cUTI | Yes | NA |
P. aeruginosa 1821383 B-E | 0.25 | 32 | 128 | 128 | 128 | 128 | 16 | 2,240 | as lower cUTI | Yes | NA |
P. aeruginosa 2062713 B-Q | 0.38 | 8 | 4 | 4 | 4 | 4 | 2 | 104 | s lower cUTI | MF | Indistinguishable |
S. aureus 1889640 A-Z | 0.06 | 256 | 128 | 128 | 128 | 64 | 64 | 3,072 | as lower cUTI | Yes | NA |
S. epidermidis 1949822 B-J | 8 | 4 | 4 | 2 | 4 | 2 | 1 | 64 | as lower cUTI | MF | Unrelated |
Eleven patients were treated with doripenem and 16 with levofloxacin. MF, microbiological failure; CF, clinical failure; s, symptomatic; as, asymptomatic.
Two strains isolated per patient.