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Mutual influence between TMC435350 and IFN-α as analyzed by the Loewe additivity model. Huh7-Luc replicon cells were treated for 72 h with compound combinations. The combination index value for an effective dose of 50%, 75%, or 90% inhibition (ED50, ED75, and ED90, respectively) was calculated. The graph is a representative example of the data in Table 2.
