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Time-dependent exposure after single oral administration of 40 mg/kg TMC435350 in plasma and liver tissue of Sprague-Dawley rats. Plasma (⧫) and liver (▴) tissue concentrations of TMC435350 are plotted over time, and EC50, EC90, and EC99 values as determined for TMC435350 in Huh7-Luc replicon cells are indicated. Each point represents the mean value for three rats.
