TABLE 1.
Antiviral activity of TMC435350 in genotype 1a and 1b repliconsa
| Replicon cell line (readout) | Subtype | EC50 (nM)
|
EC90 (nM)
|
No. of independent measurements | ||
|---|---|---|---|---|---|---|
| Median | IQRb | Median | IQR | |||
| Huh7-Luc (luciferase) | 1b | 8.1 | 4.5-11.9 | 23.6 | 15.3-28.2 | 134 |
| Huh7-Luc (qRT-PCR) | 1b | 13.0 | 11.3-14.4 | 28.7 | 27.6-57.3 | 21 |
| Huh7-SGcon1b (qRT-PCR) | 1b | 25.2 | 17.9-34.6 | 118.0 | 102.4-144.6 | 17 |
| Huh7-SG1a H77 (qRT-PCR) | 1a | 28.4 | 19.0-39.7 | 120.4 | 104.4-187.0 | 19 |
a
Inhibition of HCV RNA replication in three different HCV replicon cell lines using luciferase or qRT-PCR readout is shown.
b
IQR, interquartile range.