TABLE 2.

Mutual influence between TMC435350 and IFN-α, ribavirin, NM-107, and HCV-796 as analyzed by the Loewe additivity model^a

Combination compound	CI value for:			Influenceb
	ED50	ED75	ED90
IFN-α	0.77	0.57	0.43	Synergistic
Ribavirin	0.98	0.94	0.92	Additive
NM-107	0.58	0.64	0.64	Synergistic
HCV-796	0.86	0.88	0.92	Additive to synergistic

^aHuh7-Luc replicon cells were treated for 72 h with combinations of the compounds shown, and the combination index (CI) value for ED₅₀, ED₇₅, or ED₉₀ was calculated.

^bCI values of <0.9, 0.9 to 1.1, and >1.1 indicate synergy, an additive effect, or antagonism, respectively.