TABLE 4.
Individual pharmacokinetics of caspofungin in infants/toddlers
| Patient | Age (mo) | AUC0-24 (μg/ml·h)
|
C1 (μg/ml)
|
C24 (μg/ml)
|
β-Phase t1/2 (h)
|
CL (ml/min/m2)
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 4 | Day 1 | Day 4 | Day 1 | Day 3-14a | Day 1 | Day 4 | Day 1 | ||
| 1 | 12 | 109.4 | 135.0 | 17.53 | 24.79 | 0.65 | 0.94 | 5.02 | 10.51 | 7.30 |
| 2 | 10 | 159.6 | 114.0 | 14.47 | 15.17 | 2.38 | 1.55 | 9.00 | 9.15 | 4.37 |
| 3 | 12 | 119.5 | 122.0 | 18.26 | 15.94 | 1.03 | 1.26 | 6.64 | 6.17 | 6.44 |
| 4 | 13 | 121.4 | 15.75 | 16.87 | 1.48 | 8.35 | ||||
| 5 | 17 | 146.3 | 135.3 | 23.91 | 16.42 | 1.85 | 1.60 | 8.37 | 7.33 | 4.94 |
| 6 | 20 | 97.4 | 122.0 | 13.00 | 12.14 | 1.55 | 2.16 | 11.07 | 11.41 | 6.82 |
| 7 | 17 | 101.7 | 13.90 | 1.15 | 8.59 | 7.19 | ||||
| 8 | 12 | 128.9 | 22.30 | 17.96 | 1.72 | 8.58 | ||||
| 9 | 22 | 119.9 | 171.1 | 21.50 | 21.30 | 1.51 | 3.17 | 8.97 | 12.13 | 5.98 |
| Mean | 121.97 | 131.21 | 17.85 | 17.57 | 1.45 | 1.74 | 7.79b | 8.8b | 6.15 | |
| SD | 23.06 | 17.69 | 3.95 | 3.89 | 0.57 | 0.68 | 2.31b | 2.1b | 1.12 | |
| Geometric mean | 120.2 | 130.28 | 17.46 | 17.21 | 1.34 | 1.64 | 6.05c | |||
a
Time-averaged parameters determined as the geometric mean of all values obtained between days 3 and 14.
b
Harmonic means (jackknife standard deviations) are reported for β-phase t1/2.
c
95% CI for the geometric mean, (4.92, 7.45).