FIG. 3.

Physiological differences between WT and PDFI-resistant strains. (A) Gene categories to which the 333 significantly regulated genes belong. Custom compare analysis of the complete B. subtilis transcriptome of the WT and resistant strains was performed on microarrays at Eurogentech (Herstaing, Belgium). (B) The doubling times of the WT and Δfmt-114 strain were studied in MH medium or MM supplemented with the indicated carbon source. The fitness cost corresponds to the ratio of the doubling time of the WT with that of the resistant derivative. TCA, tricarboxylic acid.