TABLE 1.
Organism | Drug | MIC (μg/ml) for strainsa with phenotype:
|
|||||||
---|---|---|---|---|---|---|---|---|---|
Methicillin susceptible
|
Methicillin resistant
|
Tmps
|
Tmpr
|
||||||
Range | 50%/90% | Range | 50%/90% | Range | 50%/90% | Range | 50%/90% | ||
S. aureus | BAL0030543 | 0.016->32 | 0.03/0.25 | ≤0.008->32 | 0.03/0.25 | ≤0.008-0.125 | 0.03/0.03 | 0.06->32 | 0.25/0.5 |
BAL0030544 | ≤0.008->32 | 0.03/0.25 | ≤0.008->32 | 0.03/0.125 | ≤0.008-0.06 | 0.03/0.03 | 0.03->32 | 0.25/0.5 | |
BAL0030545 | ≤0.008->32 | 0.03/0.25 | ≤0.008->32 | 0.03/0.25 | ≤0.008-0.125 | 0.03/0.06 | 0.03->32 | 0.25/0.5 | |
Trimethoprim | 0.25->128 | 0.5/>128 | ≤0.008->128 | 0.5/>128 | ≤0.008-2 | 0.5/0.5 | 32->128 | >128/>128 | |
Vancomycin | 0.5-8 | 1/2 | 0.5->32 | 1/2 | 0.5->32 | 1/2 | 0.5->32 | 1/4 | |
Linezolid | 1-2 | 2/2 | 0.25-2 | 2/2 | 0.25-2 | 2/2 | 1-2 | 1/2 | |
Clindamycin | ≤0.06->32 | 0.125/>32 | ≤0.06->32 | >32/>32 | ≤0.06->32 | >32/>32 | ≤0.06->32 | >32/>32 | |
Minocycline | 0.016-2 | 0.125/0.25 | 0.03-16 | 0.125/2 | 0.03-16 | 0.125/0.25 | 0.016-8 | 0.25/8 | |
Rifampin | ≤0.004-0.03 | 0.008/0.016 | ≤0.004->16 | 0.016/0.016 | ≤0.004->16 | 0.016/0.016 | ≤0.004->16 | 0.008/>16 | |
CoNS | BAL0030543 | ≤0.008-2 | 0.016/0.06 | ≤0.008->32 | 0.06/0.5 | ≤0.008-0.125 | 0.016/0.03 | 0.016->32 | 0.125/0.5 |
BAL0030544 | ≤0.008-2 | 0.016/0.03 | ≤0.008->32 | 0.06/0.5 | ≤0.008-0.125 | 0.016/0.03 | 0.016->32 | 0.125/0.5 | |
BAL0030545 | ≤0.008-4 | 0.03/0.06 | ≤0.008->32 | 0.06/0.5 | ≤0.008-0.125 | 0.03/0.06 | 0.03->32 | 0.125/1 | |
Trimethoprim | 0.06-128 | 0.25/64 | 0.03->128 | 128/>128 | 0.03-4 | 0.25/2 | 16->128 | >128/>128 | |
Vancomycin | 0.5-2 | 1/2 | 0.5-8 | 2/2 | 0.5-2 | 1/2 | 1-8 | 2/2 | |
Linezolid | 1-2 | 1/2 | 1->16 | 1/2 | 1-2 | 1/2 | 1->16 | 1/2 | |
Clindamycin | 0.125 | 0.125/0.125 | ≤0.06->32 | 0.25/>32 | ≤0.06->32 | 0.125/>32 | 0.125->32 | 2/>32 | |
Minocycline | 0.125-0.5 | 0.125/0.5 | 0.06-16 | 0.25/1 | 0.06-16 | 0.125/1 | 0.06-2 | 0.5/0.5 | |
Rifampin | ≤0.004-0.016 | ≤0.004/0.016 | ≤0.004->16 | 0.008/2 | ≤0.004->16 | 0.008/0.016 | ≤0.004->16 | 0.008/>16 |
Numbers of strains were as follows: for S. aureus, 26 methicillin susceptible, 127 methicillin resistant, 125 Tmps, and 28 Tmpr, and for CoNS, 25 methicillin susceptible, 135 methicillin resistant, 58 Tmps, and 102 Tmpr.