TABLE 3.
Drug (no. of strains tested) and dose | No. of strains showing indicated % of killing at:
|
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
3 h
|
6 h
|
12 h
|
24 h
|
|||||||||
90 | 99 | 99.9 | 90 | 99 | 99.9 | 90 | 99 | 99.9 | 90 | 99 | 99.9 | |
BAL0030543 (12 strains) | ||||||||||||
4× MIC | 4 | 0 | 0 | 12 | 6 | 0 | 12 | 12 | 5 | 12 | 12 | 11 |
2× MIC | 4 | 0 | 0 | 12 | 6 | 0 | 12 | 12 | 4 | 12 | 12 | 11 |
1× MIC | 3 | 0 | 0 | 12 | 4 | 0 | 12 | 8 | 3 | 8 | 6 | 6 |
BAL0030544 (12 strains) | ||||||||||||
4× MIC | 6 | 1 | 0 | 12 | 8 | 2 | 12 | 12 | 9 | 12 | 12 | 11 |
2× MIC | 5 | 1 | 0 | 12 | 7 | 2 | 12 | 12 | 8 | 11 | 10 | 9 |
1× MIC | 3 | 1 | 0 | 11 | 7 | 2 | 11 | 8 | 4 | 8 | 6 | 3 |
BAL0030545 (12 strains) | ||||||||||||
4× MIC | 5 | 0 | 0 | 12 | 7 | 1 | 12 | 12 | 7 | 12 | 11 | 11 |
2× MIC | 3 | 0 | 0 | 12 | 8 | 2 | 12 | 12 | 6 | 11 | 11 | 10 |
1× MIC | 3 | 0 | 0 | 10 | 4 | 1 | 10 | 8 | 4 | 9 | 6 | 5 |
Trimethoprim (5 strains) | ||||||||||||
4× MIC | 3 | 0 | 0 | 5 | 4 | 0 | 5 | 5 | 2 | 5 | 5 | 4 |
2× MIC | 3 | 0 | 0 | 5 | 3 | 0 | 5 | 5 | 3 | 5 | 5 | 3 |
1× MIC | 2 | 0 | 0 | 5 | 2 | 0 | 5 | 4 | 3 | 3 | 2 | 2 |
Vancomycin (11 strains) | ||||||||||||
4× MIC | 6 | 1 | 0 | 10 | 6 | 3 | 10 | 9 | 4 | 11 | 10 | 10 |
2× MIC | 5 | 0 | 0 | 9 | 5 | 2 | 10 | 7 | 3 | 10 | 8 | 7 |
1× MIC | 5 | 0 | 0 | 8 | 5 | 1 | 8 | 5 | 2 | 8 | 6 | 6 |
Linezolid (11 strains) | ||||||||||||
4× MIC | 1 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 8 | 2 | 0 |
2× MIC | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | 0 | 8 | 1 | 0 |
1× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 |
Clindamycin (7 strains) | ||||||||||||
4× MIC | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 7 | 1 | 0 |
2× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 7 | 3 | 0 |
1× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 0 | 0 |
Minocycline (12 strains) | ||||||||||||
4× MIC | 1 | 0 | 0 | 3 | 0 | 0 | 8 | 0 | 0 | 10 | 2 | 0 |
2× MIC | 1 | 0 | 0 | 3 | 0 | 0 | 4 | 0 | 0 | 7 | 2 | 0 |
1× MIC | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | 0 |
Rifampin (11 strains) | ||||||||||||
4× MIC | 7 | 3 | 1 | 9 | 3 | 2 | 11 | 6 | 1 | 11 | 9 | 5 |
2× MIC | 5 | 3 | 1 | 9 | 3 | 1 | 9 | 5 | 1 | 10 | 8 | 2 |
1× MIC | 4 | 0 | 0 | 8 | 1 | 0 | 9 | 2 | 0 | 5 | 3 | 1 |