TABLE 5.
MIC changes as a consequence of serial passage
| Strain | Antifolate | Change in MIC (Δlog2)a resulting from passage:
|
|
|---|---|---|---|
| With antibiotic | Without antibiotic | ||
| S. aureus ATCC 29213 | BAL0030543 | +8 | ND |
| BAL0030544 | +3 | ND | |
| BAL0030545 | +4 | ND | |
| SA505 | BAL0030543 | +6 | ND |
| BAL0030544 | +8 | ND | |
| BAL0030545 | +6 | ND | |
| S. aureus ATCC 43300 | BAL0030543 | +7 | ND |
| BAL0030544 | +5 | ND | |
| BAL0030545 | +5 | ND | |
| SA145 | BAL0030543 | +9 | −4 |
| BAL0030544 | +10 | 0 | |
| BAL0030545 | +9 | 0 | |
| VRS1 | BAL0030543 | +9 | −1 |
| BAL0030544 | +10 | 0 | |
| BAL0030545 | +8 | 0 | |
| CN051 | BAL0030543 | +8 | −2 |
| BAL0030544 | +11 | −6 | |
| BAL0030545 | +7 | −6 | |
| CN057 | BAL0030543 | +4 | 0 |
| BAL0030544 | +5 | −1 | |
| BAL0030545 | +5 | −1 | |
| CN197 | BAL0030543 | +5 | ND |
| BAL0030544 | +1 | ND | |
| BAL0030545 | +4 | ND | |
| CN225 | BAL0030543 | +9 | −4 |
| BAL0030544 | +10 | −7 | |
| BAL0030545 | +10 | −7 | |
| CN345 | BAL0030543 | +7 | −3 |
| BAL0030544 | +12 | −7 | |
| BAL0030545 | +6 | −1 | |
a
MIC changes as a consequence of serial passage in the presence of subinhibitory concentrations of dihydrophthalazine antifolates and subsequent passage (10 times) in antibiotic-free medium are expressed as log2 dilution steps (Δlog2). ND, not determined.