TABLE 7.
Resistance frequencies of staphylococcal strains by single-step methodology
| Straina | Drug | Resistance frequency at:
|
||
|---|---|---|---|---|
| 2× MIC | 4× MIC | 8× MIC | ||
| S. aureus | BAL0030543 | 3.1 × 10−6 | 4.6 × 10−8 | 2.3 × 10−9 |
| ATCC 29213 | BAL0030544 | 4.5 × 10−9 | 3.5 × 10−9 | <5.0 × 10−11 |
| BAL0030545 | 9.0 × 10−9 | <3.3 × 10−11 | <3.3 × 10−11 | |
| Trimethoprim | 3.0 × 10−6 | 1.5 × 10−7 | 9.0 × 10−9 | |
| Vancomycin | <4.5 × 10−11 | <4.5 × 10−11 | <4.5 × 10−11 | |
| Linezolid | <7.1 × 10−11 | <7.1 × 10−11 | <7.1 × 10−11 | |
| Clindamycin | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Minocycline | <4.5 × 10−11 | <4.5 × 10−11 | <4.5 × 10−11 | |
| Rifampin | 5.4 × 10−8 | 4.6 × 10−8 | <4.6 × 10−8 | |
| SA505 | BAL0030543 | 3.0 × 10−8 | 6.0 × 10−9 | <5.0 × 10−11 |
| BAL0030544 | 1.7 × 10−8 | <5.0 × 10−11 | <5.0 × 10−11 | |
| BAL0030545 | 2.8 × 10−9 | <4.0 × 10−11 | <4.0 × 10−11 | |
| Trimethoprim | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Vancomycin | <4.5 × 10−11 | <4.5 × 10−11 | <4.5 × 10−11 | |
| Linezolid | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Clindamycin | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Minocycline | <4.0 × 10−11 | <4.0 × 10−11 | <4.0 × 10−11 | |
| Rifampin | 1.3 × 10−7 | 9.3 × 10−8 | 9.1 × 10−8 | |
| S. aureus | BAL0030543 | 5.9 × 10−8 | 1.2 × 10−8 | <5.9 × 10−11 |
| ATCC 43300 | BAL0030544 | 2.7 × 10−8 | <4.5 × 10−11 | <4.5 × 10−11 |
| BAL0030545 | 4.0 × 10−9 | <4.0 × 10−11 | <4.0 × 10−11 | |
| Trimethoprim | 3.0 × 10−7 | 5.0 × 10−9 | 3.0 × 10−9 | |
| Vancomycin | <5.3 × 10−11 | <5.3 × 10−11 | <5.3 × 10−11 | |
| Linezolid | <1.4 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 | |
| Clindamycin | Not tested | Not tested | Not tested | |
| Minocycline | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Rifampin | 1.7 × 10−7 | 1.2 × 10−7 | <1.2 × 10−7 | |
| SA145 | BAL0030543 | 2.1 × 10−7 | 6.9 × 10−8 | <3.4 × 10−11 |
| BAL0030544 | 2.2 × 10−6 | <4.0 × 10−11 | <4.0 × 10−11 | |
| BAL0030545 | <4.0 × 10−11 | <4.0 × 10−11 | <4.0 × 10−11 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Linezolid | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Clindamycin | Not tested | Not tested | Not tested | |
| Minocycline | <7.7 × 10−11 | <7.7 × 10−11 | <7.7 × 10−11 | |
| Rifampin | >5.0 × 10−8 | 5.0 × 10−8 | 2.0 × 10−8 | |
| VRS1 | BAL0030543 | 2.9 × 10−6 | 4.3 × 10−9 | <4.3 × 10−9 |
| BAL0030544 | 6.8 × 10−9 | 1.6 × 10−10 | <5.3 × 10−11 | |
| BAL0030545 | 4.5 × 10−6 | 9.1 × 10−10 | <4.5 × 10−11 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | Not tested | Not tested | Not tested | |
| Linezolid | <1.4 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 | |
| Clindamycin | Not tested | Not tested | Not tested | |
| Minocycline | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Rifampin | Not tested | Not tested | Not tested | |
| CN051 | BAL0030543 | >3.2 × 10−5 | 3.2 × 10−5 | <5.3 × 10−8 |
| BAL0030544 | 7.1 × 10−5 | 7.1 × 10−6 | 2.4 × 10−7 | |
| BAL0030545 | 2.7 × 10−5 | 1.8 × 10−7 | <9.1 × 10−8 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | <8.3 × 10−11 | <8.3 × 10−11 | <8.3 × 10−11 | |
| Linezolid | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Clindamycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 | |
| Minocycline | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Rifampin | 1.0 × 10−7 | 2.9 × 10−8 | 2.1 × 10−8 | |
| CN057 | BAL0030543 | 4.0 × 10−5 | 8.0 × 10−6 | 3.2 × 10−6 |
| BAL0030544 | 8.0 × 10−5 | 4.8 × 10−5 | 1.6 × 10−5 | |
| BAL0030545 | 1.7 × 10−4 | 8.6 × 10−5 | 4.6 × 10−5 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 | |
| Linezolid | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Clindamycin | 6.7 × 10−9 | 1.7 × 10−10 | <8.3 × 10−11 | |
| Minocycline | <1.3 × 10−10 | <1.3 × 10−10 | <1.3 × 10−10 | |
| Rifampin | >4.0 × 10−8 | 4.0 × 10−8 | 2.7 × 10−8 | |
| CN197 | BAL0030543 | 3.3 × 10−6 | 3.3 × 10−7 | 3.3 × 10−8 |
| BAL0030544 | 3.3 × 10−6 | 1.7 × 10−7 | 8.3 × 10−8 | |
| BAL0030545 | 3.7 × 10−7 | 3.3 × 10−7 | 2.2 × 10−9 | |
| Trimethoprim | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Vancomycin | <6.3 × 10−11 | <6.3 × 10−11 | <6.3 × 10−11 | |
| Linezolid | <5.6 × 10−11 | <5.6 × 10−11 | <5.6 × 10−11 | |
| Clindamycin | <6.7 × 10−11 | <6.7 × 10−11 | <6.7 × 10−11 | |
| Minocycline | 1.7 × 10−9 | <8.3 × 10−11 | <8.3 × 10−11 | |
| Rifampin | 7.1 × 10−8 | 1.4 × 10−8 | 1.3 × 10−8 | |
| CN225 | BAL0030543 | 2.7 × 10−7 | 7.8 × 10−9 | 3.9 × 10−10 |
| BAL0030544 | 4.2 × 10−6 | 3.7 × 10−8 | 3.1 × 10−9 | |
| BAL0030545 | 9.0 × 10−8 | <3.3 × 10−10 | <3.3 × 10−10 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | <2.0 × 10−10 | <2.0 × 10−10 | <2.0 × 10−10 | |
| Linezolid | <1.8 × 10−10 | <1.8 × 10−10 | <1.8 × 10−10 | |
| Clindamycin | Not tested | Not tested | Not tested | |
| Minocycline | 4.0 × 10−9 | <1.0 × 10−9 | <1.0 × 10−9 | |
| Rifampin | >2.7 × 10−8 | 2.7 × 10−8 | 2.0 × 10−8 | |
| CN345 | BAL0030543 | 4.6 × 10−5 | <7.7 × 10−8 | <7.7 × 10−8 |
| BAL0030544 | 3.3 × 10−7 | 3.3 × 10−9 | 1.7 × 10−9 | |
| BAL0030545 | 2.9 × 10−5 | 5.9 × 10−7 | 2.0 × 10−8 | |
| Trimethoprim | Not tested | Not tested | Not tested | |
| Vancomycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 | |
| Linezolid | <5.0 × 10−11 | <5.0 × 10−11 | <5.0 × 10−11 | |
| Clindamycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 | |
| Minocycline | <3.4 × 10−10 | <3.4 × 10−10 | <3.4 × 10−10 | |
| Rifampin | 4.6 × 10−8 | 3.1 × 10−8 | 2.3 × 10−8 | |
a
For strain descriptions, see Table 4.