FIG. 1.

Production of platensimycin (•) and platencin (⧫) by S. platensis MA7327, SB12001, and SB12002. (a) Structures of platensimycin and platencin; (b) HPLC traces of the crude extracts from 0.5 ml of MA7327 (i), 30 μl of SB12001 (iii), and 30 μl of SB12002 (iv) fermented under the reported platensimycin production conditions (14) and from 3 ml of MA7327 (ii) fermented under the reported platencin production conditions (8). The amount of production culture analyzed by HPLC was adjusted for different strains to ensure that the final peak areas fell within the linear range for quantitative determination of the platensimycin and platencin yields.