TABLE 1.

Cytokine levels in spleen cell supernatants from mice immunized via different routes

Vaccination group	Cytokine concn (pg/ml)a
	IFN-γ	IL-12	IL-4	IL-10	TNF-α	TGF-β
Groups after immunization
Control	21 ± 3	22 ± 3	15 ± 2	16 ± 4	11 ± 1	93 ± 16
Liposomes i.p.	22 ± 3	24 ± 3	14 ± 2	20 ± 1	13 ± 5	105 ± 6
Liposomes s.c.	23 ± 4	22 ± 2	13 ± 3	18 ± 4	12 ± 2	102 ± 8
Liposomal LAg i.p.	120 ± 7b	95 ± 8b	48 ± 5b	22 ± 4	19 ± 5	114 ± 6
Liposomal LAg s.c.	28 ± 3	25 ± 3	21 ± 3	31 ± 3	14 ± 4	924 ± 87b
Groups 4 mo after infection
Control	31 ± 2	27 ± 4	93 ± 8	230 ± 21	24 ± 4	1,652 ± 81
Liposomes i.p.	37 ± 2	28 ± 3	87 ± 8	228 ± 14	24 ± 3	1,624 ± 113
Liposomes s.c.	32 ± 4	30 ± 4	86 ± 6	220 ± 11	29 ± 4	1,540 ± 125
Liposomal LAg i.p.	274 ± 18b	168 ± 10b	37 ± 4b	33 ± 4b	126 ± 9b	113 ± 9b
Liposomal LAg s.c.	38 ± 3	32 ± 3	97 ± 7	228 ± 8	28 ± 4	1,680 ± 77

^aData are for five mice and are expressed as means ± standard errors. Data are representative of two independent experiments with similar results.

^bP < 0.001 in comparison to control groups.