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Role of proinflammatory cytokines on CXC chemokine production by corneal fibroblasts and macrophages. Corneal fibroblasts or peritoneal macrophages were stimulated with IFN-γ, TNF-α, IL-1α, IL-1β, or IL-6 for 18 h, and the production of the CXC chemokines KC and LIX was determined by ELISA. Note that corneal fibroblasts, but not macrophages, produce CXC chemokines in response to TNF-α, IL-1α, and IL-1β. The data are representative of three repeat experiments.
