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. 2009 Jan 21;77(4):1349–1356. doi: 10.1128/IAI.01434-08

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Copyright © 2009, American Society for Microbiology

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FIG. 4. — Histology of the frontal cortex and basal ganglia of T. cruzi-infected C57BL/6 mouse. H&E stains of sagittal sections of the brain from a C57BL/6 mouse 18 days after intranasal inoculation are shown. (A) Three cellular foci in the frontal cortex (CX). Original magnification, ×200. Enhanced magnification (×400) of the indicated areas reveals microglia (open arrowhead) surrounding infected cells (closed arrow). (B) Uninfected basal ganglia. Magnification, ×200. (C) One cellular focus in the striatal tissue of the basal ganglia (BG) showing a microglial nodule (open arrowhead) surrounding infected cells (closed arrow). Original magnification, ×400. Additionally, infected F4/80-positive macrophage-like cells (presumably microglia) were found within nodules (inset). Bar, 50 μm.