FIG. 1.

Schematic representation of central yeast metabolism, including the synthetic pathway for formate production. Some of the intermediates and metabolic branching points are not illustrated for simplicity. Bold arrows represent heterologous reactions. Dashed lines represent native pathways. PFL is from E. coli, FDH1/2 represents the native FDH1 and -2 from S. cerevisiae, and AdhE represents acetaldehyde/alcohol dehydrogenase E from E. coli. The X represents the deletion of the FDH1 and -2 genes.